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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: loland cj. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239
Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
Ku TC, Cao J, Won SJ, Guo J, Camacho-Hernandez GA, Okorom AV, Salomon KW, Lee KH, Loland CJ, Duff HJ, Shi L, Newman AH. Ku TC, et al. Among authors: loland cj. ACS Pharmacol Transl Sci. 2024 Jan 5;7(2):515-532. doi: 10.1021/acsptsci.3c00322. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357284 Free PMC article.
Structure of the human dopamine transporter in complex with cocaine.
Nielsen JC, Salomon K, Kalenderoglou IE, Bargmeyer S, Pape T, Shahsavar A, Loland CJ. Nielsen JC, et al. Among authors: loland cj. Nature. 2024 Aug;632(8025):678-685. doi: 10.1038/s41586-024-07804-3. Epub 2024 Aug 7. Nature. 2024. PMID: 39112703
Transmembrane transporter proteins: Capturing transport in motion.
Loland CJ, Wellendorph P, Pedersen SF, Gether U. Loland CJ, et al. Basic Clin Pharmacol Toxicol. 2024 Feb;134(2):203-205. doi: 10.1111/bcpt.13960. Epub 2023 Nov 23. Basic Clin Pharmacol Toxicol. 2024. PMID: 37945540 No abstract available.
Persistent binding at dopamine transporters determines sustained psychostimulant effects.
Niello M, Sideromenos S, Gradisch R, O Shea R, Schwazer J, Maier J, Kastner N, Sandtner W, Jäntsch K, Lupica CR, Hoffman AF, Lubec G, Loland CJ, Stockner T, Pollak DD, Baumann MH, Sitte HH. Niello M, et al. Among authors: loland cj. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2114204120. doi: 10.1073/pnas.2114204120. Epub 2023 Feb 2. Proc Natl Acad Sci U S A. 2023. PMID: 36730201 Free PMC article.
116 results