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Page 1
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.
Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO. Ruderisch N, et al. Among authors: baumann k. EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7. EBioMedicine. 2017. PMID: 28923680 Free PMC article.
Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.
Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H. Bohrmann B, et al. Among authors: baumann k. J Alzheimers Dis. 2012;28(1):49-69. doi: 10.3233/JAD-2011-110977. J Alzheimers Dis. 2012. PMID: 21955818 Free article.
Generation of a homozygous GBA deletion human embryonic stem cell line.
Gündner AL, Meyer CA, Aigner S, Christensen K, Patsch C, Jagasia R, Baumann K, Burcin M. Gündner AL, et al. Among authors: baumann k. Stem Cell Res. 2017 Aug;23:122-126. doi: 10.1016/j.scr.2017.07.009. Epub 2017 Jul 11. Stem Cell Res. 2017. PMID: 28925361 Free article.
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Page RM, et al. Among authors: baumann k. J Biol Chem. 2008 Jan 11;283(2):677-83. doi: 10.1074/jbc.M708754200. Epub 2007 Oct 24. J Biol Chem. 2008. PMID: 17962197 Free article.
Novel γ-secretase enzyme modulators directly target presenilin protein.
Ebke A, Luebbers T, Fukumori A, Shirotani K, Haass C, Baumann K, Steiner H. Ebke A, et al. Among authors: baumann k. J Biol Chem. 2011 Oct 28;286(43):37181-6. doi: 10.1074/jbc.C111.276972. Epub 2011 Sep 6. J Biol Chem. 2011. PMID: 21896486 Free PMC article.
Aminothiazoles as γ-secretase modulators.
Lübbers T, Flohr A, Jolidon S, David-Pierson P, Jacobsen H, Ozmen L, Baumann K. Lübbers T, et al. Among authors: baumann k. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6554-8. doi: 10.1016/j.bmcl.2011.08.060. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21924610
Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: baumann k. Mol Psychiatry. 2015 Oct;20(10):1179-87. doi: 10.1038/mp.2015.74. Epub 2015 Jun 9. Mol Psychiatry. 2015. PMID: 26055427 Free PMC article.
Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET.
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Brendel M, et al. Among authors: baumann k. Mol Psychiatry. 2015 Oct;20(10):1141. doi: 10.1038/mp.2015.146. Mol Psychiatry. 2015. PMID: 26401838 No abstract available.
825 results