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Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
Colley CS, Popovic B, Sridharan S, Debreczeni JE, Hargeaves D, Fung M, An LL, Edwards B, Arnold J, England E, Eghobamien L, Sivars U, Flavell L, Renshaw J, Wickson K, Warrener P, Zha J, Bonnell J, Woods R, Wilkinson T, Dobson C, Vaughan TJ. Colley CS, et al. Among authors: arnold j. MAbs. 2018 Jan;10(1):104-117. doi: 10.1080/19420862.2017.1384892. Epub 2017 Oct 24. MAbs. 2018. PMID: 28952876 Free PMC article.
Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays.
Neal F, Arnold J, Rossant CJ, Podichetty S, Lowne D, Dobson C, Wilkinson T, Colley C, Howes R, Vaughan TJ. Neal F, et al. Among authors: arnold j. J Biomol Screen. 2016 Jan;21(1):24-34. doi: 10.1177/1087057115610070. Epub 2015 Oct 8. J Biomol Screen. 2016. PMID: 26450103
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC. Dobson CL, et al. Among authors: arnold j. Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644. Sci Rep. 2016. PMID: 27995962 Free PMC article.
Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
Hall G, Cullen E, Sawmynaden K, Arnold J, Fox S, Cowan R, Muskett FW, Matthews D, Merritt A, Kettleborough C, Cruikshank W, Taylor D, Bayliss R, Carr MD. Hall G, et al. Among authors: arnold j. J Biol Chem. 2016 Aug 5;291(32):16840-8. doi: 10.1074/jbc.M115.709303. Epub 2016 May 26. J Biol Chem. 2016. PMID: 27231345 Free PMC article.
Conjoint specification of action by neocortex and striatum.
Park J, Polidoro P, Fortunato C, Arnold J, Mensh B, Gallego JA, Dudman JT. Park J, et al. Among authors: arnold j. Neuron. 2025 Jan 16:S0896-6273(24)00922-X. doi: 10.1016/j.neuron.2024.12.024. Online ahead of print. Neuron. 2025. PMID: 39837325
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent.
Klein M, Das A, Bera SC, Anderson TK, Kocincova D, Lee HW, Wang B, Papini FS, Marecki JC, Arnold JJ, Cameron CE, Raney KD, Artsimovitch I, Götte M, Kirchdoerfer RN, Depken M, Dulin D. Klein M, et al. Among authors: arnold jj. bioRxiv [Preprint]. 2025 Jan 10:2025.01.10.632299. doi: 10.1101/2025.01.10.632299. bioRxiv. 2025. PMID: 39829827 Free PMC article. Preprint.
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer.
Acha-Sagredo A, Andrei P, Clayton K, Taggart E, Antoniotti C, Woodman CA, Afrache H, Fourny C, Armero M, Moinudeen HK, Green M, Bhardwaj N, Mikolajczak A, Rodriguez-Lopez M, Crawford M, Connick E, Lim S, Hobson P, Linares J, Ignatova E, Pelka D, Smyth EC, Diamantis N, Sosnowska D, Carullo M, Ciraci P, Bergamo F, Intini R, Nye E, Barral P, Mishto M, Arnold JN, Lonardi S, Cremolini C, Fontana E, Rodriguez-Justo M, Ciccarelli FD. Acha-Sagredo A, et al. Among authors: arnold jn. Cancer Cell. 2025 Jan 13:S1535-6108(24)00483-5. doi: 10.1016/j.ccell.2024.12.008. Online ahead of print. Cancer Cell. 2025. PMID: 39824178 Free article.
Synthesis and characterization of isostructural annulated actinocenes.
Russo DR, Branson JA, Kelly SN, Sen A, Gunther SO, Peterson A, Smith PW, Ouellette ET, Arnold J, Autschbach J, Minasian SG. Russo DR, et al. Among authors: arnold j. Chem Commun (Camb). 2025 Jan 17. doi: 10.1039/d4cc06094f. Online ahead of print. Chem Commun (Camb). 2025. PMID: 39820218
2,890 results