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Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Mori Y, Ogawa Y, Mochizuki A, Nakamura Y, Sugita C, Miyazaki S, Tamaki K, Matsui Y, Takahashi M, Nagayama T, Nagai Y, Inoue S, Nishi T. Mori Y, et al. Among authors: nakamura y. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7677-82. doi: 10.1016/j.bmcl.2012.09.103. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23122821
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Namiki H, Suzuki S, Asano M, Sugita C, Mochizuki A, Miyazaki S, Tamaki K, Nagai Y, Inoue S, Nagayama T, Kato M, Chiba K, Takasuna K, Nishi T. Nakamura Y, et al. Bioorg Med Chem. 2013 Jun 1;21(11):3175-96. doi: 10.1016/j.bmc.2013.03.022. Epub 2013 Mar 26. Bioorg Med Chem. 2013. PMID: 23598247
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Mori Y, Ogawa Y, Mochizuki A, Nakamura Y, Fujimoto T, Sugita C, Miyazaki S, Tamaki K, Nagayama T, Nagai Y, Inoue S, Chiba K, Nishi T. Mori Y, et al. Among authors: nakamura y. Bioorg Med Chem. 2013 Sep 15;21(18):5907-22. doi: 10.1016/j.bmc.2013.06.057. Epub 2013 Jul 2. Bioorg Med Chem. 2013. PMID: 23886807
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Sugita C, Miyazaki S, Tamaki K, Takahashi M, Matsui Y, Nagayama T, Manabe K, Mizuno M, Masubuchi N, Chiba K, Nishi T. Nakamura Y, et al. ACS Med Chem Lett. 2012 Aug 18;3(9):754-8. doi: 10.1021/ml300168e. eCollection 2012 Sep 13. ACS Med Chem Lett. 2012. PMID: 24900544 Free PMC article.
Treatment of emphysematous polycystic renal infection in patients with autosomal dominant polycystic kidney disease: Feasibility and limitations of percutaneous cyst drainage.
Sugimoto H, Suwabe T, Kurihara S, Oba Y, Ikuma D, Mizuno H, Sekine A, Yamanouchi M, Miki K, Yokoyama T, Nakamura Y, Ishii Y, Wada T, Sawa N, Ubara Y. Sugimoto H, et al. Among authors: nakamura y. Clin Nephrol Case Stud. 2024 Dec 20;12:83-89. doi: 10.5414/CNCS111450. eCollection 2024. Clin Nephrol Case Stud. 2024. PMID: 39776936 Free PMC article.
Efficiency of Skeletal Muscle Mass/Weight Measurement for Distinguishing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Analysis Using InBody Bioimpedance Devices.
Tatsuta M, Masaki T, Kimura S, Sato Y, Tomida A, Ishikawa I, Nakamura Y, Takuma K, Nakahara M, Oura K, Tadokoro T, Fujita K, Tani J, Morishita A, Himoto T, Miyazaki S, Maeta T, Mori Y, Kohi F, Kobara H. Tatsuta M, et al. Among authors: nakamura y. Nutrients. 2024 Dec 23;16(24):4422. doi: 10.3390/nu16244422. Nutrients. 2024. PMID: 39771043
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