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Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
Huang SN, Pommier Y, Marchand C. Huang SN, et al. Expert Opin Ther Pat. 2011 Sep;21(9):1285-92. doi: 10.1517/13543776.2011.604314. Expert Opin Ther Pat. 2011. PMID: 21843105 Free PMC article. Review.
The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).
Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K. Tsuda M, et al. Among authors: huang sn. Oncotarget. 2017 May 16;8(20):33457-33474. doi: 10.18632/oncotarget.16508. Oncotarget. 2017. PMID: 28380422 Free PMC article.
Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.
Huang SN, Dalla Rosa I, Michaels SA, Tulumello DV, Agama K, Khiati S, Jean SR, Baechler SA, Factor VM, Varma S, Murai J, Miller Jenkins LM, Kelley SO, Pommier Y. Huang SN, et al. EMBO Rep. 2018 Mar;19(3):e42139. doi: 10.15252/embr.201642139. Epub 2018 Feb 9. EMBO Rep. 2018. PMID: 29438979 Free PMC article.
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis.
Baechler SA, Factor VM, Dalla Rosa I, Ravji A, Becker D, Khiati S, Miller Jenkins LM, Lang M, Sourbier C, Michaels SA, Neckers LM, Zhang HL, Spinazzola A, Huang SN, Marquardt JU, Pommier Y. Baechler SA, et al. Among authors: huang sn. Nat Commun. 2019 Jan 8;10(1):83. doi: 10.1038/s41467-018-07922-3. Nat Commun. 2019. PMID: 30622257 Free PMC article.
208 results