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Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen.
de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. de Jesus Cortez F, et al. Among authors: webb p. ACS Chem Biol. 2017 Dec 15;12(12):2934-2939. doi: 10.1021/acschembio.7b00702. Epub 2017 Nov 2. ACS Chem Biol. 2017. PMID: 28981251
A surface on the androgen receptor that allosterically regulates coactivator binding.
Estébanez-Perpiñá E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. Estébanez-Perpiñá E, et al. Among authors: webb p. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16074-9. doi: 10.1073/pnas.0708036104. Epub 2007 Oct 2. Proc Natl Acad Sci U S A. 2007. PMID: 17911242 Free PMC article.
Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Yumoto F, et al. Among authors: webb p. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):143-8. doi: 10.1073/pnas.1117036108. Epub 2011 Dec 20. Proc Natl Acad Sci U S A. 2012. PMID: 22187462 Free PMC article.
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Borngraeber S, et al. Among authors: webb p. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15358-63. doi: 10.1073/pnas.2136689100. Epub 2003 Dec 12. Proc Natl Acad Sci U S A. 2003. PMID: 14673100 Free PMC article.
1,348 results