Kawanishi M - Search Results

1

A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators.

Atobe M, Yamakawa N, Wada Y, Goto T, Kawanishi M, Ito T, Saito M, Takeda M, Tabata T, Arai H. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4828-4831. doi: 10.1016/j.bmcl.2017.09.049. Epub 2017 Sep 25. Bioorg Med Chem Lett. 2017. PMID: 28988762

2

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.

Atobe M, Maekawara N, Ishiguro N, Sogame S, Suenaga Y, Kawanishi M, Suzuki H, Jinno N, Tanaka E, Miyoshi S. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2106-10. doi: 10.1016/j.bmcl.2013.01.121. Epub 2013 Feb 9. Bioorg Med Chem Lett. 2013. PMID: 23453070

3

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors.

Atobe M, Maekawara N, Kawanishi M, Suzuki H, Tanaka E, Miyoshi S. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2111-6. doi: 10.1016/j.bmcl.2013.01.120. Epub 2013 Feb 9. Bioorg Med Chem Lett. 2013. PMID: 23453072

4

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6064-7. doi: 10.1016/j.bmcl.2013.09.032. Epub 2013 Sep 19. Bioorg Med Chem Lett. 2013. PMID: 24094816

5

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6569-76. doi: 10.1016/j.bmcl.2013.10.065. Epub 2013 Nov 6. Bioorg Med Chem Lett. 2013. PMID: 24252546

6

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP(1) receptor antagonists for treatment of overactive bladder by core structure replacement.

Atobe M, Naganuma K, Kawanishi M, Morimoto A, Kasahara K, Ohashi S, Suzuki H, Hayashi T, Miyoshi S. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1327-33. doi: 10.1016/j.bmcl.2014.01.052. Epub 2014 Jan 28. Bioorg Med Chem Lett. 2014. PMID: 24508133

7

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP₁ receptor antagonist and in vivo studies in a bone fracture model.

Atobe M, Naganuma K, Kawanishi M, Hayashi T, Suzuki H, Nishida M, Arai H. Atobe M, et al. Among authors: kawanishi m. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2408-2412. doi: 10.1016/j.bmcl.2018.06.022. Epub 2018 Jun 19. Bioorg Med Chem Lett. 2018. PMID: 29934246

8

Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis.

Atobe M, Nagami T, Muramatsu S, Ohno T, Kitagawa M, Suzuki H, Ishiguro M, Watanabe A, Kawanishi M. Atobe M, et al. Among authors: kawanishi m. J Med Chem. 2019 Feb 14;62(3):1468-1483. doi: 10.1021/acs.jmedchem.8b01615. Epub 2019 Jan 28. J Med Chem. 2019. PMID: 30629441

9

Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ζ Inhibitors with Fragment-Merging Strategy.

Atobe M, Serizawa T, Yamakawa N, Takaba K, Nagano Y, Yamaura T, Tanaka E, Tazumi A, Bito S, Ishiguro M, Kawanishi M. Atobe M, et al. Among authors: kawanishi m. J Med Chem. 2020 Jul 9;63(13):7143-7162. doi: 10.1021/acs.jmedchem.0c00449. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32551607

10

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.

Sogame S, Suenaga Y, Atobe M, Kawanishi M, Tanaka E, Miyoshi S. Sogame S, et al. Among authors: kawanishi m. Eur J Med Chem. 2014 Jan;71:250-8. doi: 10.1016/j.ejmech.2013.10.075. Epub 2013 Nov 15. Eur J Med Chem. 2014. PMID: 24316668

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