Gray NS - Search Results

1

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

Kalan S, Amat R, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Kalan S, et al. Among authors: gray ns. Cell Rep. 2017 Oct 10;21(2):467-481. doi: 10.1016/j.celrep.2017.09.056. Cell Rep. 2017. PMID: 29020632 Free PMC article.

2

Discovery of selective aminothiazole aurora kinase inhibitors.

Andersen CB, Wan Y, Chang JW, Riggs B, Lee C, Liu Y, Sessa F, Villa F, Kwiatkowski N, Suzuki M, Nallan L, Heald R, Musacchio A, Gray NS. Andersen CB, et al. Among authors: gray ns. ACS Chem Biol. 2008 Mar 20;3(3):180-92. doi: 10.1021/cb700200w. Epub 2008 Feb 29. ACS Chem Biol. 2008. PMID: 18307303

3

Targeting cancer with small molecule kinase inhibitors.

Zhang J, Yang PL, Gray NS. Zhang J, et al. Among authors: gray ns. Nat Rev Cancer. 2009 Jan;9(1):28-39. doi: 10.1038/nrc2559. Nat Rev Cancer. 2009. PMID: 19104514 Review.

4

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. Peterson TR, et al. Among authors: gray ns. Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14. Cell. 2009. PMID: 19446321 Free PMC article.

5

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Kwiatkowski N, et al. Among authors: gray ns. Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11. Nat Chem Biol. 2010. PMID: 20383151 Free PMC article.

6

Discovery of selective irreversible inhibitors for EGFR-T790M.

Zhou W, Ercan D, Jänne PA, Gray NS. Zhou W, et al. Among authors: gray ns. Bioorg Med Chem Lett. 2011 Jan 15;21(2):638-43. doi: 10.1016/j.bmcl.2010.12.036. Epub 2010 Dec 10. Bioorg Med Chem Lett. 2011. PMID: 21208802 Free PMC article.

7

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Miduturu CV, et al. Among authors: gray ns. Chem Biol. 2011 Jul 29;18(7):868-79. doi: 10.1016/j.chembiol.2011.05.010. Chem Biol. 2011. PMID: 21802008 Free PMC article.

8

Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen.

Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N. Kwiatkowski N, et al. ACS Chem Biol. 2012 Jan 20;7(1):185-96. doi: 10.1021/cb200305u. Epub 2011 Oct 21. ACS Chem Biol. 2012. PMID: 21992004 Free PMC article.

9

Discovery of potent and selective covalent inhibitors of JNK.

Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Zhang T, et al. Among authors: gray ns. Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010. Chem Biol. 2012. PMID: 22284361 Free PMC article.

10

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

Zhang Z, Kwiatkowski N, Zeng H, Lim SM, Gray NS, Zhang W, Yang PL. Zhang Z, et al. Among authors: gray ns. Mol Biosyst. 2012 Oct;8(10):2523-6. doi: 10.1039/c2mb25099c. Mol Biosyst. 2012. PMID: 22673640 Free PMC article.

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