Lin YS - Search Results

1

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: lin ys. PLoS One. 2017 Oct 16;12(10):e0186447. doi: 10.1371/journal.pone.0186447. eCollection 2017. PLoS One. 2017. PMID: 29036218 Free PMC article.

2

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.

Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Lin YS, et al. J Med Chem. 2012 Apr 12;55(7):3201-15. doi: 10.1021/jm201657x. Epub 2012 Mar 19. J Med Chem. 2012. PMID: 22390415

3

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.

De Schutter JW, Shaw J, Lin YS, Tsantrizos YS. De Schutter JW, et al. Among authors: lin ys. Bioorg Med Chem. 2012 Sep 15;20(18):5583-91. doi: 10.1016/j.bmc.2012.07.019. Epub 2012 Jul 24. Bioorg Med Chem. 2012. PMID: 22884353

4

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: lin ys. BMC Struct Biol. 2012 Dec 12;12:32. doi: 10.1186/1472-6807-12-32. BMC Struct Biol. 2012. PMID: 23234314 Free PMC article.

5

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.

Park J, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: lin ys. Acta Crystallogr F Struct Biol Commun. 2014 Mar;70(Pt 3):299-304. doi: 10.1107/S2053230X14002106. Epub 2014 Feb 19. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24598914 Free PMC article.

6

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.

De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. De Schutter JW, et al. Among authors: lin ys. J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23. J Med Chem. 2014. PMID: 24911527

7

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.

Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Gritzalis D, et al. Among authors: lin ys. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1117-23. doi: 10.1016/j.bmcl.2014.12.089. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25630225

8

Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.

Lacbay CM, Mancuso J, Lin YS, Bennett N, Götte M, Tsantrizos YS. Lacbay CM, et al. Among authors: lin ys. J Med Chem. 2014 Sep 11;57(17):7435-49. doi: 10.1021/jm501010f. Epub 2014 Aug 29. J Med Chem. 2014. PMID: 25144111

9

Correlation Between PIK3R1 Expression and Cell Growth in Human Breast Cancer Cell Line BT-474 and Clinical Outcomes.

Tsai YF, Lai JI, Liu CY, Hsi CN, Hsu CY, Huang CC, Feng CJ, Lin YS, Chao TC, Chiu JH, Tseng LM. Tsai YF, et al. Among authors: lin ys. World J Oncol. 2025 Feb;16(1):131-141. doi: 10.14740/wjon1986. Epub 2025 Jan 10. World J Oncol. 2025. PMID: 39850525 Free PMC article.

10

Typhoid Fever as a Cause of Liver Failure in the United States: A Case Report.

Baqir SM, Sharma N, Lutaf A, Ghitan M, Lin YS. Baqir SM, et al. Among authors: lin ys. Case Rep Gastrointest Med. 2025 Jan 13;2025:3087201. doi: 10.1155/crgm/3087201. eCollection 2025. Case Rep Gastrointest Med. 2025. PMID: 39840122 Free PMC article.

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