Igaki K - Search Results

1

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.

Shibata A, Kuno M, Adachi R, Sato Y, Hattori H, Matsuda A, Okuzono Y, Igaki K, Tominari Y, Takagi T, Yabuki M, Okaniwa M. Shibata A, et al. Among authors: igaki k. PLoS One. 2017 Oct 24;12(10):e0186587. doi: 10.1371/journal.pone.0186587. eCollection 2017. PLoS One. 2017. PMID: 29065190 Free PMC article.

2

Pharmacological evaluation of TAK-828F, a novel orally available RORγt inverse agonist, on murine chronic experimental autoimmune encephalomyelitis model.

Nakamura Y, Igaki K, Uga K, Shibata A, Yamauchi H, Yamasaki M, Tsuchimori N. Nakamura Y, et al. Among authors: igaki k. J Neuroimmunol. 2019 Oct 15;335:577016. doi: 10.1016/j.jneuroim.2019.577016. Epub 2019 Jul 25. J Neuroimmunol. 2019. PMID: 31374381

3

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist.

Shibata A, Uga K, Sato T, Sagara M, Igaki K, Nakamura Y, Ochida A, Kono M, Shirai J, Yamamoto S, Yamasaki M, Tsuchimori N. Shibata A, et al. Among authors: igaki k. Biochem Pharmacol. 2018 Apr;150:35-45. doi: 10.1016/j.bcp.2018.01.023. Epub 2018 Jan 31. Biochem Pharmacol. 2018. PMID: 29369782

4

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model.

Igaki K, Nakamura Y, Komoike Y, Uga K, Shibata A, Ishimura Y, Yamasaki M, Tsukimi Y, Tsuchimori N. Igaki K, et al. Inflammation. 2019 Feb;42(1):91-102. doi: 10.1007/s10753-018-0875-7. Inflammation. 2019. PMID: 30121880

5

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease.

Igaki K, Nakamura Y, Tanaka M, Mizuno S, Yoshimatsu Y, Komoike Y, Uga K, Shibata A, Imaichi H, Takayuki S, Ishimura Y, Yamasaki M, Kanai T, Tsukimi Y, Tsuchimori N. Igaki K, et al. Inflamm Res. 2019 Jun;68(6):493-509. doi: 10.1007/s00011-019-01234-y. Epub 2019 Apr 10. Inflamm Res. 2019. PMID: 30972425

6

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.

Kono M, Ochida A, Oda T, Imada T, Banno Y, Taya N, Masada S, Kawamoto T, Yonemori K, Nara Y, Fukase Y, Yukawa T, Tokuhara H, Skene R, Sang BC, Hoffman ID, Snell GP, Uga K, Shibata A, Igaki K, Nakamura Y, Nakagawa H, Tsuchimori N, Yamasaki M, Shirai J, Yamamoto S. Kono M, et al. Among authors: igaki k. J Med Chem. 2018 Apr 12;61(7):2973-2988. doi: 10.1021/acs.jmedchem.8b00061. Epub 2018 Mar 14. J Med Chem. 2018. PMID: 29510038

7

MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model.

Igaki K, Komoike Y, Nakamura Y, Watanabe T, Yamasaki M, Fleming P, Yang L, Soler D, Fedyk E, Tsuchimori N. Igaki K, et al. Int Immunopharmacol. 2018 Jul;60:160-169. doi: 10.1016/j.intimp.2018.04.049. Epub 2018 May 4. Int Immunopharmacol. 2018. PMID: 29730559

8

Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling.

Nakamura Y, Yokoyama K, Igaki K, Tsuchimori N. Nakamura Y, et al. Among authors: igaki k. Int Immunopharmacol. 2018 Mar;56:193-196. doi: 10.1016/j.intimp.2018.01.028. Epub 2018 Feb 3. Int Immunopharmacol. 2018. PMID: 29414650

9

Malt1 inactivation attenuates experimental colitis through the regulation of Th17 and Th1/17 cells.

Nakamura Y, Igaki K, Komoike Y, Yokoyama K, Tsuchimori N. Nakamura Y, et al. Among authors: igaki k. Inflamm Res. 2019 Mar;68(3):223-230. doi: 10.1007/s00011-018-1207-y. Epub 2018 Dec 18. Inflamm Res. 2019. PMID: 30564895

10

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors.

Miwatashi S, Arikawa Y, Naruo K, Igaki K, Watanabe Y, Kimura H, Kawamoto T, Ohkawa S. Miwatashi S, et al. Among authors: igaki k. Chem Pharm Bull (Tokyo). 2005 Apr;53(4):410-8. doi: 10.1248/cpb.53.410. Chem Pharm Bull (Tokyo). 2005. PMID: 15802841 Free article.

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