Lüthi U - Search Results

1

The Screening Compound Collection: A Key Asset for Drug Discovery.

Boss C, Hazemann J, Kimmerlin T, von Korff M, Lüthi U, Peter O, Sander T, Siegrist R. Boss C, et al. Among authors: luthi u. Chimia (Aarau). 2017 Oct 25;71(10):667-677. doi: 10.2533/chimia.2017.667. Chimia (Aarau). 2017. PMID: 29070412 Free article.

2

Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors.

Sieber P, Schäfer A, Lieberherr R, Le Goff F, Stritt M, Welford RWD, Gatfield J, Peter O, Nayler O, Lüthi U. Sieber P, et al. Among authors: luthi u. PLoS One. 2018 Nov 28;13(11):e0207872. doi: 10.1371/journal.pone.0207872. eCollection 2018. PLoS One. 2018. PMID: 30485339 Free PMC article.

3

A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.

Lotz-Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, Wirth M, Pavan S, Bill R, Regenass U, Christofori G, Meyer-Schaller N. Lotz-Jenne C, et al. Among authors: luthi u. Oncotarget. 2016 May 3;7(18):25983-6002. doi: 10.18632/oncotarget.8418. Oncotarget. 2016. PMID: 27036020 Free PMC article.

4

Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase.

Middendorp O, Lüthi U, Hausch F, Barberis A. Middendorp O, et al. Among authors: luthi u. Biol Chem. 2004 Jun;385(6):481-5. doi: 10.1515/BC.2004.056. Biol Chem. 2004. PMID: 15255179 Review.

5

Human beta-secretase activity in yeast detected by a novel cellular growth selection system.

Lüthi U, Schaerer-Brodbeck C, Tanner S, Middendorp O, Edler K, Barberis A. Lüthi U, et al. Biochim Biophys Acta. 2003 Mar 17;1620(1-3):167-78. doi: 10.1016/s0304-4165(02)00529-9. Biochim Biophys Acta. 2003. PMID: 12595086

6

Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase.

Middendorp O, Ortler C, Neumann U, Paganetti P, Lüthi U, Barberis A. Middendorp O, et al. Among authors: luthi u. Biochim Biophys Acta. 2004 Sep 6;1674(1):29-39. doi: 10.1016/j.bbagen.2004.05.004. Biochim Biophys Acta. 2004. PMID: 15342111

7

Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations.

Huang D, Lüthi U, Kolb P, Edler K, Cecchini M, Audetat S, Barberis A, Caflisch A. Huang D, et al. Among authors: luthi u. J Med Chem. 2005 Aug 11;48(16):5108-11. doi: 10.1021/jm050499d. J Med Chem. 2005. PMID: 16078830

8

Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format.

Cottier V, Barberis A, Lüthi U. Cottier V, et al. Among authors: luthi u. Antimicrob Agents Chemother. 2006 Feb;50(2):565-71. doi: 10.1128/AAC.50.2.565-571.2006. Antimicrob Agents Chemother. 2006. PMID: 16436711 Free PMC article.

9

In silico discovery of beta-secretase inhibitors.

Huang D, Lüthi U, Kolb P, Cecchini M, Barberis A, Caflisch A. Huang D, et al. Among authors: luthi u. J Am Chem Soc. 2006 Apr 26;128(16):5436-43. doi: 10.1021/ja0573108. J Am Chem Soc. 2006. PMID: 16620115

10

Yeast as a screening tool.

Barberis A, Gunde T, Berset C, Audetat S, Lüthi U. Barberis A, et al. Among authors: luthi u. Drug Discov Today Technol. 2005 Summer;2(2):187-92. doi: 10.1016/j.ddtec.2005.05.022. Drug Discov Today Technol. 2005. PMID: 24981847

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