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IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C, Mantovani A. Molgora M, et al. Nature. 2017 Nov 2;551(7678):110-114. doi: 10.1038/nature24293. Epub 2017 Oct 25. Nature. 2017. PMID: 29072292 Free PMC article.
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A. Bonavita E, et al. Among authors: molgora m. Cell. 2015 Feb 12;160(4):700-714. doi: 10.1016/j.cell.2015.01.004. Cell. 2015. PMID: 25679762 Free article.
Regulatory Role of IL-1R8 in Immunity and Disease.
Molgora M, Barajon I, Mantovani A, Garlanda C. Molgora M, et al. Front Immunol. 2016 Apr 20;7:149. doi: 10.3389/fimmu.2016.00149. eCollection 2016. Front Immunol. 2016. PMID: 27148268 Free PMC article. Review.
High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity.
Campesato LF, Silva APM, Cordeiro L, Correa BR, Navarro FCP, Zanin RF, Marçola M, Inoue LT, Duarte ML, Molgora M, Pasqualini F, Massara M, Galante P, Barroso-Sousa R, Polentarutti N, Riva F, Costa ET, Mantovani A, Garlanda C, Camargo AA. Campesato LF, et al. Among authors: molgora m. Oncotarget. 2017 Jul 25;8(30):49470-49483. doi: 10.18632/oncotarget.17713. Oncotarget. 2017. PMID: 28533483 Free PMC article.
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, Magrini E, Gianni F, Kunderfranco P, Polentarutti N, Pasqualini F, Di Marco S, Supino D, Peano C, Cananzi F, Colombo P, Pilotti S, Alomar SY, Bonavita E, Galdiero MR, Garlanda C, Mantovani A, Jaillon S. Ponzetta A, et al. Among authors: molgora m. Cell. 2019 Jul 11;178(2):346-360.e24. doi: 10.1016/j.cell.2019.05.047. Epub 2019 Jun 27. Cell. 2019. PMID: 31257026 Free PMC article.
The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.
Mattiola I, Tomay F, De Pizzol M, Silva-Gomes R, Savino B, Gulic T, Doni A, Lonardi S, Astrid Boutet M, Nerviani A, Carriero R, Molgora M, Stravalaci M, Morone D, Shalova IN, Lee Y, Biswas SK, Mantovani G, Sironi M, Pitzalis C, Vermi W, Bottazzi B, Mantovani A, Locati M. Mattiola I, et al. Among authors: molgora m. Nat Immunol. 2019 Aug;20(8):1012-1022. doi: 10.1038/s41590-019-0417-y. Epub 2019 Jul 1. Nat Immunol. 2019. PMID: 31263276 Free PMC article.
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