Das T - Search Results

1

Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.

Huang Y, Fu J, Ludwig R, Tao L, Bongers J, Ma L, Yao M, Zhu M, Das T, Russell R. Huang Y, et al. Among authors: das t. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:193-200. doi: 10.1016/j.jchromb.2017.08.046. Epub 2017 Oct 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 29078145

2

Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities.

Song H, Xu J, Jin M, Huang C, Bongers J, Bai H, Wu W, Ludwig R, Li Z, Tao L, Das TK. Song H, et al. Pharm Res. 2016 Apr;33(4):932-41. doi: 10.1007/s11095-015-1839-3. Epub 2015 Dec 10. Pharm Res. 2016. PMID: 26658915

3

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.

Yan Y, Wei H, Fu Y, Jusuf S, Zeng M, Ludwig R, Krystek SR Jr, Chen G, Tao L, Das TK. Yan Y, et al. Anal Chem. 2016 Feb 16;88(4):2041-50. doi: 10.1021/acs.analchem.5b02800. Epub 2016 Jan 29. Anal Chem. 2016. PMID: 26824491

4

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G. Huang RY, et al. J Am Soc Mass Spectrom. 2017 May;28(5):795-802. doi: 10.1007/s13361-016-1452-7. Epub 2016 Aug 15. J Am Soc Mass Spectrom. 2017. PMID: 27527097

5

Comparative study of therapeutic antibody candidates derived from mini-pool and clonal cell lines.

Fan L, Rizzi G, Bierilo K, Tian J, Yee JC, Russell R, Das TK. Fan L, et al. Biotechnol Prog. 2017 Nov;33(6):1456-1462. doi: 10.1002/btpr.2477. Epub 2017 May 2. Biotechnol Prog. 2017. PMID: 28393481

6

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.

Yan Y, Wei H, Jusuf S, Krystek SR Jr, Chen J, Chen G, Ludwig RT, Tao L, Das TK. Yan Y, et al. Among authors: das tk. J Pharm Sci. 2017 Nov;106(11):3222-3229. doi: 10.1016/j.xphs.2017.06.009. Epub 2017 Jun 17. J Pharm Sci. 2017. PMID: 28634122

7

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.

Jiang T, Song H, Slaney TR, Wu W, Langsdorf E, Gupta G, Ludwig R, Tao L, McVey D, Das TK. Jiang T, et al. Among authors: das tk. Anal Chem. 2017 Dec 5;89(23):12749-12755. doi: 10.1021/acs.analchem.7b02914. Epub 2017 Nov 14. Anal Chem. 2017. PMID: 29086552

8

Challenges and new frontiers in analytical characterization of antibody-drug conjugates.

Wagh A, Song H, Zeng M, Tao L, Das TK. Wagh A, et al. MAbs. 2018 Feb/Mar;10(2):222-243. doi: 10.1080/19420862.2017.1412025. Epub 2018 Jan 5. MAbs. 2018. PMID: 29293399 Free PMC article. Review.

9

A three-point identity criteria tool for establishing product identity using icIEF method.

Ahluwalia D, Belakavadi M, Das TK, Katiyar A. Ahluwalia D, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083:271-277. doi: 10.1016/j.jchromb.2018.02.042. Epub 2018 Mar 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29554523

10

Detection and Identification of the Vibrational Markers for the Quantification of Methionine Oxidation in Therapeutic Proteins.

Balakrishnan G, Barnett GV, Kar SR, Das TK. Balakrishnan G, et al. Anal Chem. 2018 Jun 5;90(11):6959-6966. doi: 10.1021/acs.analchem.8b01238. Epub 2018 May 17. Anal Chem. 2018. PMID: 29741878

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