Shears SB - Search Results

1

KO of 5-InsP₇ kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype.

Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. Gu C, et al. Among authors: shears sb. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11968-11973. doi: 10.1073/pnas.1702370114. Epub 2017 Oct 25. Proc Natl Acad Sci U S A. 2017. PMID: 29078269 Free PMC article.

2

Telomere maintenance by intracellular signals: new kid on the block?

Shears SB. Shears SB. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1811-2. doi: 10.1073/pnas.0409801102. Epub 2005 Jan 31. Proc Natl Acad Sci U S A. 2005. PMID: 15684046 Free PMC article. No abstract available.

3

Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress.

Choi JH, Williams J, Cho J, Falck JR, Shears SB. Choi JH, et al. Among authors: shears sb. J Biol Chem. 2007 Oct 19;282(42):30763-75. doi: 10.1074/jbc.M704655200. Epub 2007 Aug 16. J Biol Chem. 2007. PMID: 17702752 Free PMC article.

4

Diphosphoinositol polyphosphates: what are the mechanisms?

Shears SB, Gokhale NA, Wang H, Zaremba A. Shears SB, et al. Adv Enzyme Regul. 2011;51(1):13-25. doi: 10.1016/j.advenzreg.2010.09.008. Epub 2010 Oct 28. Adv Enzyme Regul. 2011. PMID: 21035493 Free PMC article. Review.

5

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Wang H, Falck JR, Hall TM, Shears SB. Wang H, et al. Among authors: shears sb. Nat Chem Biol. 2011 Nov 27;8(1):111-6. doi: 10.1038/nchembio.733. Nat Chem Biol. 2011. PMID: 22119861 Free PMC article.

6

Defining signal transduction by inositol phosphates.

Shears SB, Ganapathi SB, Gokhale NA, Schenk TM, Wang H, Weaver JD, Zaremba A, Zhou Y. Shears SB, et al. Subcell Biochem. 2012;59:389-412. doi: 10.1007/978-94-007-3015-1_13. Subcell Biochem. 2012. PMID: 22374098 Free PMC article. Review.

7

Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

Zhou Y, Wu S, Wang H, Hayakawa Y, Bird GS, Shears SB. Zhou Y, et al. Among authors: shears sb. Biochem J. 2012 Dec 1;448(2):273-83. doi: 10.1042/BJ20120730. Biochem J. 2012. PMID: 22928859 Free PMC article.

8

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase.

Riley AM, Wang H, Weaver JD, Shears SB, Potter BV. Riley AM, et al. Among authors: shears sb. Chem Commun (Camb). 2012 Nov 28;48(92):11292-4. doi: 10.1039/c2cc36044f. Chem Commun (Camb). 2012. PMID: 23032903 Free PMC article.

9

Structural insight into inositol pyrophosphate turnover.

Shears SB, Weaver JD, Wang H. Shears SB, et al. Adv Biol Regul. 2013 Jan;53(1):19-27. doi: 10.1016/j.jbior.2012.10.002. Epub 2012 Oct 11. Adv Biol Regul. 2013. PMID: 23107997 Free PMC article. Review.

10

The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment.

Weaver JD, Wang H, Shears SB. Weaver JD, et al. Among authors: shears sb. Biosci Rep. 2013 Feb 5;33(2):e00022. doi: 10.1042/BSR20120115. Biosci Rep. 2013. PMID: 23240582 Free PMC article.

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