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Page 1
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir.
Ng TI, Tripathi R, Reisch T, Lu L, Middleton T, Hopkins TA, Pithawalla R, Irvin M, Dekhtyar T, Krishnan P, Schnell G, Beyer J, McDaniel KF, Ma J, Wang G, Jiang LJ, Or YS, Kempf D, Pilot-Matias T, Collins C. Ng TI, et al. Among authors: middleton t. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01620-17. doi: 10.1128/AAC.01620-17. Print 2018 Jan. Antimicrob Agents Chemother. 2017. PMID: 29084747 Free PMC article.
Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon system.
He Y, King MS, Kempf DJ, Lu L, Lim HB, Krishnan P, Kati W, Middleton T, Molla A. He Y, et al. Among authors: middleton t. Antimicrob Agents Chemother. 2008 Mar;52(3):1101-10. doi: 10.1128/AAC.01149-07. Epub 2007 Dec 17. Antimicrob Agents Chemother. 2008. PMID: 18086851 Free PMC article.
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450.
Pilot-Matias T, Tripathi R, Cohen D, Gaultier I, Dekhtyar T, Lu L, Reisch T, Irvin M, Hopkins T, Pithawalla R, Middleton T, Ng T, McDaniel K, Or YS, Menon R, Kempf D, Molla A, Collins C. Pilot-Matias T, et al. Among authors: middleton t. Antimicrob Agents Chemother. 2015 Feb;59(2):988-97. doi: 10.1128/AAC.04227-14. Epub 2014 Dec 1. Antimicrob Agents Chemother. 2015. PMID: 25451053 Free PMC article. Clinical Trial.
Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.
Chen CM, He Y, Lu L, Lim HB, Tripathi RL, Middleton T, Hernandez LE, Beno DW, Long MA, Kati WM, Bosse TD, Larson DP, Wagner R, Lanford RE, Kohlbrenner WE, Kempf DJ, Pilot-Matias TJ, Molla A. Chen CM, et al. Among authors: middleton t. Antimicrob Agents Chemother. 2007 Dec;51(12):4290-6. doi: 10.1128/AAC.00723-07. Epub 2007 Oct 1. Antimicrob Agents Chemother. 2007. PMID: 17908950 Free PMC article.
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.
Krueger AC, Madigan DL, Green BE, Hutchinson DK, Jiang WW, Kati WM, Liu Y, Maring CJ, Masse SV, McDaniel KF, Middleton TR, Mo H, Molla A, Montgomery DA, Ng TI, Kempf DJ. Krueger AC, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2289-92. doi: 10.1016/j.bmcl.2007.01.072. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17300933
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.
Pratt JK, Donner P, McDaniel KF, Maring CJ, Kati WM, Mo H, Middleton T, Liu Y, Ng T, Xie Q, Zhang R, Montgomery D, Molla A, Kempf DJ, Kohlbrenner W. Pratt JK, et al. Among authors: middleton t. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1577-82. doi: 10.1016/j.bmcl.2005.01.071. Bioorg Med Chem Lett. 2005. PMID: 15745800
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
Rockway TW, Zhang R, Liu D, Betebenner DA, McDaniel KF, Pratt JK, Beno D, Montgomery D, Jiang WW, Masse S, Kati WM, Middleton T, Molla A, Maring CJ, Kempf DJ. Rockway TW, et al. Among authors: middleton t. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3833-8. doi: 10.1016/j.bmcl.2006.04.022. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650984
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
Krueger AC, Madigan DL, Jiang WW, Kati WM, Liu D, Liu Y, Maring CJ, Masse S, McDaniel KF, Middleton T, Mo H, Molla A, Montgomery D, Pratt JK, Rockway TW, Zhang R, Kempf DJ. Krueger AC, et al. Among authors: middleton t. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3367-70. doi: 10.1016/j.bmcl.2006.04.015. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650764
107 results