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Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.
Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C. Azoitei N, et al. Among authors: chiosis g. J Exp Med. 2012 Apr 9;209(4):697-711. doi: 10.1084/jem.20111910. Epub 2012 Mar 26. J Exp Med. 2012. PMID: 22451720 Free PMC article.
HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Fröhling S, Scholl C, Seufferlein T. Azoitei N, et al. Among authors: chiosis g. Cancer Res. 2014 Dec 1;74(23):7125-36. doi: 10.1158/0008-5472.CAN-14-1017. Epub 2014 Oct 8. Cancer Res. 2014. PMID: 25297628 Free PMC article.
Development and application of Hsp90 inhibitors.
Solit DB, Chiosis G. Solit DB, et al. Among authors: chiosis g. Drug Discov Today. 2008 Jan;13(1-2):38-43. doi: 10.1016/j.drudis.2007.10.007. Epub 2007 Nov 26. Drug Discov Today. 2008. PMID: 18190862 Review.
Purine-scaffold Hsp90 inhibitors.
Taldone T, Chiosis G. Taldone T, et al. Among authors: chiosis g. Curr Top Med Chem. 2009;9(15):1436-46. doi: 10.2174/156802609789895737. Curr Top Med Chem. 2009. PMID: 19860732 Free PMC article. Review.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
Taldone T, Zatorska D, Ochiana SO, Smith-Jones P, Koziorowski J, Dunphy MP, Zanzonico P, Bolaender A, Lewis JS, Larson SM, Chiosis G, Pillarsetty NV. Taldone T, et al. Among authors: chiosis g. J Labelled Comp Radiopharm. 2016 Mar;59(3):129-32. doi: 10.1002/jlcr.3369. Epub 2016 Jan 25. J Labelled Comp Radiopharm. 2016. PMID: 26806023 Free PMC article.
Proteomic interrogation of HSP90 and insights for medical research.
Weidenauer L, Wang T, Joshi S, Chiosis G, Quadroni MR. Weidenauer L, et al. Among authors: chiosis g. Expert Rev Proteomics. 2017 Dec;14(12):1105-1117. doi: 10.1080/14789450.2017.1389649. Epub 2017 Oct 16. Expert Rev Proteomics. 2017. PMID: 28990809 Free PMC article. Review.
179 results