Liu Z - Search Results

1

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Liu Z, Zhu Y, Chen H, Wang P, Mei FC, Ye N, Cheng X, Zhou J. Liu Z, et al. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5163-5166. doi: 10.1016/j.bmcl.2017.10.056. Epub 2017 Oct 25. Bioorg Med Chem Lett. 2017. PMID: 29100797 Free PMC article.

2

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Ye N, Zhu Y, Chen H, Liu Z, Mei FC, Wild C, Chen H, Cheng X, Zhou J. Ye N, et al. Among authors: liu z. J Med Chem. 2015 Aug 13;58(15):6033-47. doi: 10.1021/acs.jmedchem.5b00635. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26151319 Free PMC article.

3

Direct Activation of Bax Protein for Cancer Therapy.

Liu Z, Ding Y, Ye N, Wild C, Chen H, Zhou J. Liu Z, et al. Med Res Rev. 2016 Mar;36(2):313-41. doi: 10.1002/med.21379. Epub 2015 Sep 23. Med Res Rev. 2016. PMID: 26395559 Free PMC article. Review.

4

BH4 domain of Bcl-2 as a novel target for cancer therapy.

Liu Z, Wild C, Ding Y, Ye N, Chen H, Wold EA, Zhou J. Liu Z, et al. Drug Discov Today. 2016 Jun;21(6):989-96. doi: 10.1016/j.drudis.2015.11.008. Epub 2015 Nov 26. Drug Discov Today. 2016. PMID: 26631752 Free PMC article. Review.

5

Discovery and development of natural product oridonin-inspired anticancer agents.

Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Ding Y, et al. Among authors: liu z. Eur J Med Chem. 2016 Oct 21;122:102-117. doi: 10.1016/j.ejmech.2016.06.015. Epub 2016 Jun 13. Eur J Med Chem. 2016. PMID: 27344488 Free PMC article. Review.

6

Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Liu Z, et al. J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. J Med Chem. 2017. PMID: 28195723 Free PMC article. Review.

7

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.

Wang P, Liu Z, Chen H, Ye N, Cheng X, Zhou J. Wang P, et al. Among authors: liu z. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1633-1639. doi: 10.1016/j.bmcl.2017.02.065. Epub 2017 Feb 27. Bioorg Med Chem Lett. 2017. PMID: 28283242 Free PMC article. Review.

8

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Ye N, Zhu Y, Liu Z, Mei FC, Chen H, Wang P, Cheng X, Zhou J. Ye N, et al. Among authors: liu z. Eur J Med Chem. 2017 Jul 7;134:62-71. doi: 10.1016/j.ejmech.2017.04.001. Epub 2017 Apr 4. Eur J Med Chem. 2017. PMID: 28399451 Free PMC article.

9

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads.

Ding Y, Li D, Ding C, Wang P, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Ding Y, et al. Among authors: liu z. J Med Chem. 2018 Apr 12;61(7):2737-2752. doi: 10.1021/acs.jmedchem.7b01514. Epub 2018 Mar 20. J Med Chem. 2018. PMID: 29528645 Free PMC article.

10

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

Liu Z, Tian B, Chen H, Wang P, Brasier AR, Zhou J. Liu Z, et al. Eur J Med Chem. 2018 May 10;151:450-461. doi: 10.1016/j.ejmech.2018.04.006. Epub 2018 Apr 3. Eur J Med Chem. 2018. PMID: 29649741 Free PMC article.

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