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Pharmacological inhibition of glycogen synthase kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3β, protein interacting with C kinase and GluA2 protein expression in the reward pathway of male C57BL/6J mice.
Faccidomo S, Holstein SE, Santanam TS, Saunders BL, Swaim KS, Reid GT, O'Neill C, Eastman VR, Hodge CW. Faccidomo S, et al. Among authors: eastman vr. Behav Pharmacol. 2020 Feb;31(1):15-26. doi: 10.1097/FBP.0000000000000501. Behav Pharmacol. 2020. PMID: 31503067 Free PMC article.
Operant alcohol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Faccidomo S, et al. Among authors: eastman vr. bioRxiv [Preprint]. 2024 Nov 14:2024.09.13.612946. doi: 10.1101/2024.09.13.612946. bioRxiv. 2024. Update in: Psychopharmacology (Berl). 2024 Dec 23. doi: 10.1007/s00213-024-06740-4 PMID: 39314444 Free PMC article. Updated. Preprint.
Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Faccidomo S, et al. Among authors: eastman vr. Psychopharmacology (Berl). 2024 Dec 23. doi: 10.1007/s00213-024-06740-4. Online ahead of print. Psychopharmacology (Berl). 2024. PMID: 39714485