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Page 1
Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.
Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W. Paul DS, et al. Among authors: ghalloussi d. Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973. Blood Adv. 2017. PMID: 29104956 Free PMC article.
Functional redundancy between RAP1 isoforms in murine platelet production and function.
Stefanini L, Lee RH, Paul DS, O'Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W. Stefanini L, et al. Among authors: ghalloussi d. Blood. 2018 Nov 1;132(18):1951-1962. doi: 10.1182/blood-2018-03-838714. Epub 2018 Aug 21. Blood. 2018. PMID: 30131434 Free PMC article.
Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids.
Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, de la Salle H, Gachet C. Eckly A, et al. Among authors: ghalloussi d. J Thromb Haemost. 2020 Nov;18(11):2987-3001. doi: 10.1111/jth.15024. Epub 2020 Aug 25. J Thromb Haemost. 2020. PMID: 32702204 Free article.
Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.
Poggi M, Canault M, Favier M, Turro E, Saultier P, Ghalloussi D, Baccini V, Vidal L, Mezzapesa A, Chelghoum N, Mohand-Oumoussa B, Falaise C, Favier R, Ouwehand WH, Fiore M, Peiretti F, Morange PE, Saut N, Bernot D, Greinacher A, BioResource N, Nurden AT, Nurden P, Freson K, Trégouët DA, Raslova H, Alessi MC. Poggi M, et al. Among authors: ghalloussi d. Haematologica. 2017 Feb;102(2):282-294. doi: 10.3324/haematol.2016.147694. Epub 2016 Sep 23. Haematologica. 2017. PMID: 27663637 Free PMC article.
Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA. Canault M, et al. Among authors: ghalloussi d. J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23. J Exp Med. 2014. PMID: 24958846 Free PMC article. Clinical Trial.
ANKRD26-related thrombocytopenia and myeloid malignancies.
Noris P, Favier R, Alessi MC, Geddis AE, Kunishima S, Heller PG, Giordano P, Niederhoffer KY, Bussel JB, Podda GM, Vianelli N, Kersseboom R, Pecci A, Gnan C, Marconi C, Auvrignon A, Cohen W, Yu JC, Iguchi A, Miller Imahiyerobo A, Boehlen F, Ghalloussi D, De Rocco D, Magini P, Civaschi E, Biino G, Seri M, Savoia A, Balduini CL. Noris P, et al. Among authors: ghalloussi d. Blood. 2013 Sep 12;122(11):1987-9. doi: 10.1182/blood-2013-04-499319. Blood. 2013. PMID: 24030261 Free article. No abstract available.