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Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, Vitt D, Steingruber M, Sonntag E, Zeitträger I, Bahsi H, Stamminger T, Rawlinson W, Strobl S, Marschall M. Hutterer C, et al. Among authors: strobl s. Antiviral Res. 2017 Jul;143:113-121. doi: 10.1016/j.antiviral.2017.04.003. Epub 2017 Apr 9. Antiviral Res. 2017. PMID: 28400201
Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity.
Hahn F, Hutterer C, Henry C, Hamilton ST, Strojan H, Kraut A, Schulte U, Schütz M, Kohrt S, Wangen C, Pfizer J, Couté Y, Rawlinson WD, Strobl S, Marschall M. Hahn F, et al. Among authors: strobl s. Antiviral Res. 2018 Nov;159:84-94. doi: 10.1016/j.antiviral.2018.09.012. Epub 2018 Sep 27. Antiviral Res. 2018. PMID: 30268914
SC83288 is a clinical development candidate for the treatment of severe malaria.
Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M. Pegoraro S, et al. Among authors: strobl s. Nat Commun. 2017 Jan 31;8:14193. doi: 10.1038/ncomms14193. Nat Commun. 2017. PMID: 28139658 Free PMC article.
109 results