Mehboob S - Search Results

1

A novel series of enoyl reductase inhibitors targeting the ESKAPE pathogens, Staphylococcus aureus and Acinetobacter baumannii.

Kwon J, Mistry T, Ren J, Johnson ME, Mehboob S. Kwon J, et al. Among authors: mehboob s. Bioorg Med Chem. 2018 Jan 1;26(1):65-76. doi: 10.1016/j.bmc.2017.11.018. Epub 2017 Nov 11. Bioorg Med Chem. 2018. PMID: 29162308 Free PMC article.

2

Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan.

Mehboob S, Truong K, Santarsiero BD, Johnson ME. Mehboob S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1436-40. doi: 10.1107/S1744309110039862. Epub 2010 Oct 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 21045289 Free PMC article.

3

Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching.

Hevener KE, Mehboob S, Su PC, Truong K, Boci T, Deng J, Ghassemi M, Cook JL, Johnson ME. Hevener KE, et al. Among authors: mehboob s. J Med Chem. 2012 Jan 12;55(1):268-79. doi: 10.1021/jm201168g. Epub 2011 Dec 5. J Med Chem. 2012. PMID: 22098466 Free PMC article.

4

Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.

Mehboob S, Hevener KE, Truong K, Boci T, Santarsiero BD, Johnson ME. Mehboob S, et al. J Med Chem. 2012 Jun 28;55(12):5933-41. doi: 10.1021/jm300489v. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22642319 Free PMC article.

5

Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).

Mehboob S, Song J, Hevener KE, Su PC, Boci T, Brubaker L, Truong L, Mistry T, Deng J, Cook JL, Santarsiero BD, Ghosh AK, Johnson ME. Mehboob S, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1292-6. doi: 10.1016/j.bmcl.2015.01.048. Epub 2015 Jan 29. Bioorg Med Chem Lett. 2015. PMID: 25677657 Free PMC article.

6

Benzimidazole-Based FabI Inhibitors: A Promising Novel Scaffold for Anti-staphylococcal Drug Development.

Mistry TL, Truong L, Ghosh AK, Johnson ME, Mehboob S. Mistry TL, et al. Among authors: mehboob s. ACS Infect Dis. 2017 Jan 13;3(1):54-61. doi: 10.1021/acsinfecdis.6b00123. Epub 2016 Oct 27. ACS Infect Dis. 2017. PMID: 27756129 Free PMC article.

7

Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques.

Ren J, Mistry TL, Su PC, Mehboob S, Demissie R, Fung LW, Ghosh AK, Johnson ME. Ren J, et al. Among authors: mehboob s. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2074-2079. doi: 10.1016/j.bmcl.2018.04.052. Epub 2018 Apr 22. Bioorg Med Chem Lett. 2018. PMID: 29730028 Free PMC article.

8

Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis.

Hevener KE, Mehboob S, Boci T, Truong K, Santarsiero BD, Johnson ME. Hevener KE, et al. Among authors: mehboob s. Protein Expr Purif. 2012 Sep;85(1):100-8. doi: 10.1016/j.pep.2012.07.003. Epub 2012 Jul 20. Protein Expr Purif. 2012. PMID: 22820244 Free PMC article.

9

Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.

Zhang YY, Liu Y, Mehboob S, Song JH, Boci T, Johnson ME, Ghosh AK, Jeong H. Zhang YY, et al. Among authors: mehboob s. Xenobiotica. 2014 May;44(5):404-16. doi: 10.3109/00498254.2013.850553. Epub 2013 Oct 30. Xenobiotica. 2014. PMID: 24171690 Free PMC article.

10

Comparison of radii sets, entropy, QM methods, and sampling on MM-PBSA, MM-GBSA, and QM/MM-GBSA ligand binding energies of F. tularensis enoyl-ACP reductase (FabI).

Su PC, Tsai CC, Mehboob S, Hevener KE, Johnson ME. Su PC, et al. Among authors: mehboob s. J Comput Chem. 2015 Sep 30;36(25):1859-73. doi: 10.1002/jcc.24011. Epub 2015 Jul 27. J Comput Chem. 2015. PMID: 26216222 Free PMC article.

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