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Page 1
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.
Turcan S, Makarov V, Taranda J, Wang Y, Fabius AWM, Wu W, Zheng Y, El-Amine N, Haddock S, Nanjangud G, LeKaye HC, Brennan C, Cross J, Huse JT, Kelleher NL, Osten P, Thompson CB, Chan TA. Turcan S, et al. Among authors: lekaye hc. Nat Genet. 2018 Jan;50(1):62-72. doi: 10.1038/s41588-017-0001-z. Epub 2017 Nov 27. Nat Genet. 2018. PMID: 29180699 Free PMC article.
High-field small animal magnetic resonance oncology studies.
Bokacheva L, Ackerstaff E, LeKaye HC, Zakian K, Koutcher JA. Bokacheva L, et al. Among authors: lekaye hc. Phys Med Biol. 2014 Jan 20;59(2):R65-R127. doi: 10.1088/0031-9155/59/2/R65. Epub 2013 Dec 30. Phys Med Biol. 2014. PMID: 24374985 Free PMC article. Review.
ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.
Aytes A, Mitrofanova A, Kinkade CW, Lefebvre C, Lei M, Phelan V, LeKaye HC, Koutcher JA, Cardiff RD, Califano A, Shen MM, Abate-Shen C. Aytes A, et al. Among authors: lekaye hc. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3506-15. doi: 10.1073/pnas.1303558110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918374 Free PMC article.
Predicting Gemcitabine Delivery by 18F-FAC PET in Murine Models of Pancreatic Cancer.
Russell J, Grkovski M, O'Donoghue IJ, Kalidindi TM, Pillarsetty N, Burnazi EM, Kulick A, Bahr A, Chang Q, LeKaye HC, de Stanchina E, Yu KH, Humm JL. Russell J, et al. Among authors: lekaye hc. J Nucl Med. 2021 Feb;62(2):195-200. doi: 10.2967/jnumed.120.246926. Epub 2020 Jul 9. J Nucl Med. 2021. PMID: 32646874 Free PMC article.
High-fructose corn syrup enhances intestinal tumor growth in mice.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J. Goncalves MD, et al. Among authors: lekaye hc. Science. 2019 Mar 22;363(6433):1345-1349. doi: 10.1126/science.aat8515. Science. 2019. PMID: 30898933 Free PMC article.
Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.
Noch EK, Palma LN, Yim I, Bullen N, Qiu Y, Ravichandran H, Kim J, Rendeiro A, Davis MB, Elemento O, Pisapia DJ, Zhai K, LeKaye HC, Koutcher JA, Wen PY, Ligon KL, Cantley LC. Noch EK, et al. Among authors: lekaye hc. Neuro Oncol. 2023 Dec 8;25(12):2165-2176. doi: 10.1093/neuonc/noad117. Neuro Oncol. 2023. PMID: 37399061 Free PMC article.