Willard J - Search Results

1

Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.

Park E, Gintant GA, Bi D, Kozeli D, Pettit SD, Pierson JB, Skinner M, Willard J, Wisialowski T, Koerner J, Valentin JP. Park E, et al. Among authors: willard j. Br J Pharmacol. 2018 Feb;175(4):606-617. doi: 10.1111/bph.14101. Epub 2018 Jan 15. Br J Pharmacol. 2018. PMID: 29181850 Free PMC article.

2

The Challenges of Predicting Drug-Induced QTc Prolongation in Humans.

Valentin JP, Hoffmann P, Ortemann-Renon C, Koerner J, Pierson J, Gintant G, Willard J, Garnett C, Skinner M, Vargas HM, Wisialowski T, Pugsley MK. Valentin JP, et al. Among authors: willard j. Toxicol Sci. 2022 Apr 26;187(1):3-24. doi: 10.1093/toxsci/kfac013. Toxicol Sci. 2022. PMID: 35148401 Free PMC article. Review.

3

The impact of drug-related QT prolongation on FDA regulatory decisions.

Park E, Willard J, Bi D, Fiszman M, Kozeli D, Koerner J. Park E, et al. Among authors: willard j. Int J Cardiol. 2013 Oct 12;168(5):4975-6. doi: 10.1016/j.ijcard.2013.07.136. Epub 2013 Aug 3. Int J Cardiol. 2013. PMID: 23920061 No abstract available.

4

[No title available]

[No authors listed] [No authors listed] PMID: 31962991

5

Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs).

Narkar A, Willard JM, Blinova K. Narkar A, et al. Int J Mol Sci. 2022 Mar 16;23(6):3199. doi: 10.3390/ijms23063199. Int J Mol Sci. 2022. PMID: 35328619 Free PMC article. Review.

6

Computational identification of a phospholipidosis toxicophore using (13)C and (15)N NMR-distance based fingerprints.

Slavov SH, Wilkes JG, Buzatu DA, Kruhlak NL, Willard JM, Hanig JP, Beger RD. Slavov SH, et al. Bioorg Med Chem. 2014 Dec 1;22(23):6706-6714. doi: 10.1016/j.bmc.2014.08.021. Epub 2014 Aug 27. Bioorg Med Chem. 2014. PMID: 25228124 Free article.

7

Is randomization to placebo safe? Risk in placebo-controlled angina trials: angina risk meta-analysis.

Glasser SP, Willard J, Defelice A, Lawrence J, Hung J, Obot E, Girton J, Targum S, Throckmorton D, Mangano D, Lipicky RJ. Glasser SP, et al. Among authors: willard j. Cardiology. 2011;120(3):174-81. doi: 10.1159/000335522. Epub 2012 Jan 18. Cardiology. 2011. PMID: 22261892 Free PMC article.

8

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Kruhlak NL, Choi SS, Contrera JF, Weaver JL, Willard JM, Hastings KL, Sancilio LF. Kruhlak NL, et al. Toxicol Mech Methods. 2008;18(2-3):217-27. doi: 10.1080/15376510701857262. Toxicol Mech Methods. 2008. PMID: 20020916

9

The risks associated with short-term placebo-controlled antihypertensive clinical trials: a descriptive meta-analysis.

DeFelice A, Willard J, Lawrence J, Hung J, Gordon MA, Karkowsky A, Targum S, Throckmorton DC, Girton J, Stertz B, Glasser SP, Lipicky RJ. DeFelice A, et al. Among authors: willard j. J Hum Hypertens. 2008 Oct;22(10):659-68. doi: 10.1038/jhh.2008.51. J Hum Hypertens. 2008. PMID: 18528409

10

Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop.

Lenz B, Braendli-Baiocco A, Engelhardt J, Fant P, Fischer H, Francke S, Fukuda R, Gröters S, Harada T, Harleman H, Kaufmann W, Kustermann S, Nolte T, Palazzi X, Pohlmeyer-Esch G, Popp A, Romeike A, Schulte A, Lima BS, Tomlinson L, Willard J, Wood CE, Yoshida M. Lenz B, et al. Among authors: willard j. Toxicol Pathol. 2018 Feb;46(2):224-246. doi: 10.1177/0192623317749452. Toxicol Pathol. 2018. PMID: 29471779

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