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The pathophysiology of human obstructive cholestasis is mimicked in cholestatic Gold Syrian hamsters.
van Golen RF, Olthof PB, de Haan LR, Coelen RJ, Pechlivanis A, de Keijzer MJ, Weijer R, de Waart DR, van Kuilenburg ABP, Roelofsen J, Gilijamse PW, Maas MA, Lewis MR, Nicholson JK, Verheij J, Heger M. van Golen RF, et al. Among authors: de waart dr, de haan lr, de keijzer mj. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):942-951. doi: 10.1016/j.bbadis.2017.11.022. Epub 2017 Nov 28. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29196240 Free article.
The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.
van der Mark VA, de Waart DR, Ho-Mok KS, Tabbers MM, Voogt HW, Oude Elferink RP, Knisely AS, Paulusma CC. van der Mark VA, et al. Among authors: de waart dr. Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2378-86. doi: 10.1016/j.bbadis.2014.09.003. Epub 2014 Sep 16. Biochim Biophys Acta. 2014. PMID: 25239307 Free article.
FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis.
van Golen RF, Olthof PB, Lionarons DA, Reiniers MJ, Alles LK, Uz Z, de Haan L, Ergin B, de Waart DR, Maas A, Verheij J, Jansen PL, Damink SWO, Schaap FG, van Gulik TM, Heger M. van Golen RF, et al. Among authors: de waart dr, de haan l. Sci Rep. 2018 Nov 8;8(1):16529. doi: 10.1038/s41598-018-33070-1. Sci Rep. 2018. PMID: 30409980 Free PMC article.
99 results