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DNA repair targeted therapy: The past or future of cancer treatment?
Gavande NS, VanderVere-Carozza PS, Hinshaw HD, Jalal SI, Sears CR, Pawelczak KS, Turchi JJ. Gavande NS, et al. Pharmacol Ther. 2016 Apr;160:65-83. doi: 10.1016/j.pharmthera.2016.02.003. Epub 2016 Feb 16. Pharmacol Ther. 2016. PMID: 26896565 Free PMC article. Review.
Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction.
Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Mendoza-Munoz P, Vernon TL, Hanakahi LA, Summerlin M, Dynlacht JR, Farmer AH, Sears CR, Nasrallah NA, Garrett J, Turchi JJ. Gavande NS, et al. Among authors: vandervere carozza ps. Nucleic Acids Res. 2020 Nov 18;48(20):11536-11550. doi: 10.1093/nar/gkaa934. Nucleic Acids Res. 2020. PMID: 33119767 Free PMC article.
Small-Molecule Inhibitor Screen for DNA Repair Proteins.
Turchi JJ, VanderVere-Carozza PS. Turchi JJ, et al. Among authors: vandervere carozza ps. Methods Mol Biol. 2019;1999:217-221. doi: 10.1007/978-1-4939-9500-4_13. Methods Mol Biol. 2019. PMID: 31127579
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Turchi JJ, Johnson N, Jonkers J, Rothenberg E, Cantor SB. Cong K, et al. Among authors: vandervere carozza ps. Mol Cell. 2021 Aug 5;81(15):3128-3144.e7. doi: 10.1016/j.molcel.2021.06.011. Epub 2021 Jul 2. Mol Cell. 2021. PMID: 34216544 Free PMC article.
16 results