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A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers.
Haass-Koffler CL, Goodyear K, Long VM, Tran HH, Loche A, Cacciaglia R, Swift RM, Leggio L. Haass-Koffler CL, et al. Among authors: long vm. Eur J Pharm Sci. 2017 Nov 15;109:78-85. doi: 10.1016/j.ejps.2017.07.031. Epub 2017 Aug 1. Eur J Pharm Sci. 2017. PMID: 28778464 Free PMC article. Clinical Trial.
Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans.
Haass-Koffler CL, Goodyear K, Loche A, Long VM, Lobina C, Tran HH, Cacciaglia R, Swift RM, Colombo G, Leggio L. Haass-Koffler CL, et al. Among authors: long vm. J Psychopharmacol. 2018 Feb;32(2):163-173. doi: 10.1177/0269881117746904. Epub 2018 Jan 23. J Psychopharmacol. 2018. PMID: 29361897 Free PMC article. Clinical Trial.
Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study.
Haass-Koffler CL, Long VM, Farokhnia M, Magill M, Kenna GA, Swift RM, Leggio L. Haass-Koffler CL, et al. Among authors: long vm. Neuropharmacology. 2019 Nov 1;158:107711. doi: 10.1016/j.neuropharm.2019.107711. Epub 2019 Jul 13. Neuropharmacology. 2019. PMID: 31310775 Free PMC article.
Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.
Haass-Koffler CL, Piacentino D, Li X, Long VM, Lee MR, Swift RM, Kenna GA, Leggio L. Haass-Koffler CL, et al. Among authors: long vm. Alcohol Clin Exp Res. 2020 Oct;44(10):2097-2108. doi: 10.1111/acer.14428. Epub 2020 Sep 30. Alcohol Clin Exp Res. 2020. PMID: 32997422 Free PMC article. Clinical Trial.
Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin.
Haass-Koffler CL, Goodyear K, Zywiak WH, Magill M, Eltinge SE, Wallace PM, Long VM, Jayaram-Lindström N, Swift RM, Kenna GA, Leggio L. Haass-Koffler CL, et al. Among authors: long vm. Drug Alcohol Depend. 2017 Aug 1;177:23-28. doi: 10.1016/j.drugalcdep.2017.03.016. Epub 2017 May 16. Drug Alcohol Depend. 2017. PMID: 28551590 Free PMC article. Clinical Trial.