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Insights into the role of somatic mosaicism in the brain.
Paquola ACM, Erwin JA, Gage FH. Paquola ACM, et al. Among authors: gage fh. Curr Opin Syst Biol. 2017 Feb;1:90-94. doi: 10.1016/j.coisb.2016.12.004. Epub 2016 Dec 9. Curr Opin Syst Biol. 2017. PMID: 29226270 Free PMC article.
Differential L1 regulation in pluripotent stem cells of humans and apes.
Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. Marchetto MCN, et al. Among authors: gage fh. Nature. 2013 Nov 28;503(7477):525-529. doi: 10.1038/nature12686. Epub 2013 Oct 23. Nature. 2013. PMID: 24153179 Free PMC article.
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Mertens J, et al. Among authors: gage fh. Cell Stem Cell. 2015 Dec 3;17(6):705-718. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8. Cell Stem Cell. 2015. PMID: 26456686 Free PMC article.
Generation of functional human serotonergic neurons from fibroblasts.
Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. Vadodaria KC, et al. Among authors: gage fh. Mol Psychiatry. 2016 Jan;21(1):49-61. doi: 10.1038/mp.2015.161. Epub 2015 Oct 27. Mol Psychiatry. 2016. PMID: 26503761
The different moods of human serotonergic neurons.
Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. Vadodaria KC, et al. Among authors: gage fh. Mol Psychiatry. 2016 Jan;21(1):3. doi: 10.1038/mp.2015.202. Mol Psychiatry. 2016. PMID: 26678308 No abstract available.
A Mechanism for Somatic Brain Mosaicism.
Weissman IL, Gage FH. Weissman IL, et al. Among authors: gage fh. Cell. 2016 Feb 11;164(4):593-5. doi: 10.1016/j.cell.2016.01.048. Cell. 2016. PMID: 26871622 Free article.
Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons.
Krishnaswami SR, Grindberg RV, Novotny M, Venepally P, Lacar B, Bhutani K, Linker SB, Pham S, Erwin JA, Miller JA, Hodge R, McCarthy JK, Kelder M, McCorrison J, Aevermann BD, Fuertes FD, Scheuermann RH, Lee J, Lein ES, Schork N, McConnell MJ, Gage FH, Lasken RS. Krishnaswami SR, et al. Among authors: gage fh. Nat Protoc. 2016 Mar;11(3):499-524. doi: 10.1038/nprot.2016.015. Epub 2016 Feb 18. Nat Protoc. 2016. PMID: 26890679 Free PMC article.
Nuclear RNA-seq of single neurons reveals molecular signatures of activation.
Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJE, Parylak SL, Paquola ACM, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. Lacar B, et al. Among authors: gage fh. Nat Commun. 2016 Apr 19;7:11022. doi: 10.1038/ncomms11022. Nat Commun. 2016. PMID: 27090946 Free PMC article.
Environment-driven somatic mosaicism in brain disorders.
Bedrosian TA, Linker S, Gage FH. Bedrosian TA, et al. Among authors: gage fh. Genome Med. 2016 May 23;8(1):58. doi: 10.1186/s13073-016-0317-9. Genome Med. 2016. PMID: 27215330 Free PMC article.
868 results