Nissinen TA - Search Results

1

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R. Hulmi JJ, et al. Among authors: nissinen ta. J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11. J Cachexia Sarcopenia Muscle. 2018. PMID: 29230965 Free PMC article.

2

Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes.

Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ. Nissinen TA, et al. Sci Rep. 2016 Sep 26;6:32695. doi: 10.1038/srep32695. Sci Rep. 2016. PMID: 27666826 Free PMC article.

3

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. Räsänen M, et al. Among authors: nissinen ta. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. doi: 10.1073/pnas.1616168113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799559 Free PMC article.

4

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses.

Nissinen TA, Hentilä J, Penna F, Lampinen A, Lautaoja JH, Fachada V, Holopainen T, Ritvos O, Kivelä R, Hulmi JJ. Nissinen TA, et al. J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):514-529. doi: 10.1002/jcsm.12310. Epub 2018 May 2. J Cachexia Sarcopenia Muscle. 2018. PMID: 29722201 Free PMC article.

5

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver.

Hentilä J, Nissinen TA, Korkmaz A, Lensu S, Silvennoinen M, Pasternack A, Ritvos O, Atalay M, Hulmi JJ. Hentilä J, et al. Among authors: nissinen ta. Front Physiol. 2019 Jan 18;9:1917. doi: 10.3389/fphys.2018.01917. eCollection 2018. Front Physiol. 2019. PMID: 30713500 Free PMC article.

6

Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade.

Lautaoja JH, Lalowski M, Nissinen TA, Hentilä J, Shi Y, Ritvos O, Cheng S, Hulmi JJ. Lautaoja JH, et al. Among authors: nissinen ta. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E852-E865. doi: 10.1152/ajpendo.00526.2018. Epub 2019 Mar 12. Am J Physiol Endocrinol Metab. 2019. PMID: 30860875 Free article.

7

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota-A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?

Pekkala S, Keskitalo A, Kettunen E, Lensu S, Nykänen N, Kuopio T, Ritvos O, Hentilä J, Nissinen TA, Hulmi JJ. Pekkala S, et al. Among authors: nissinen ta. Cancers (Basel). 2019 Nov 15;11(11):1799. doi: 10.3390/cancers11111799. Cancers (Basel). 2019. PMID: 31731747 Free PMC article.

8

Muscle NAD⁺ depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins.

Hulmi JJ, Penna F, Pöllänen N, Nissinen TA, Hentilä J, Euro L, Lautaoja JH, Ballarò R, Soliymani R, Baumann M, Ritvos O, Pirinen E, Lalowski M. Hulmi JJ, et al. Among authors: nissinen ta. Mol Metab. 2020 Nov;41:101046. doi: 10.1016/j.molmet.2020.101046. Epub 2020 Jun 26. Mol Metab. 2020. PMID: 32599075 Free PMC article.

9

Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting.

Nissinen TA, Hentilä J, Fachada V, Lautaoja JH, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ. Nissinen TA, et al. FASEB J. 2021 Mar;35(3):e21387. doi: 10.1096/fj.202002008R. FASEB J. 2021. PMID: 33559263

10

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments.

Hulmi JJ, Nissinen TA, Penna F, Bonetto A. Hulmi JJ, et al. Among authors: nissinen ta. Cells. 2021 Feb 28;10(3):516. doi: 10.3390/cells10030516. Cells. 2021. PMID: 33671024 Free PMC article. Review.

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