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Page 1
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Hamdouchi C, Maiti P, Warshawsky AM, DeBaillie AC, Otto KA, Wilbur KL, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Cr S, Lineswala JP, Neathery GL, Bouaichi C, Diseroad BA, Campbell AN, Sweetana SA, Adams LA, Cabrera O, Ma X, Yumibe NP, Montrose-Rafizadeh C, Chen Y, Miller AR. Hamdouchi C, et al. Among authors: warshawsky am. J Med Chem. 2018 Feb 8;61(3):934-945. doi: 10.1021/acs.jmedchem.7b01411. Epub 2018 Jan 5. J Med Chem. 2018. PMID: 29236497
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
Shi Q, Canada EJ, Xu Y, Warshawsky AM, Etgen GJ, Broderick CL, Clutinger CK, Irwin LA, Laurila ME, Montrose-Rafizadeh C, Oldham BA, Wang M, Winneroski LL, Xie C, York JS, Yumibe NP, Zink RW, Mantlo N. Shi Q, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6744-9. doi: 10.1016/j.bmcl.2007.10.047. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2007. PMID: 18029178
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
Henry JR, Li Y, Warshawsky AM, Brozinick JT, Hawkins ED, Misener EA, Briere DA, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Ajamie RT, Wilken B, Devanarayan V. Henry JR, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6293-7. doi: 10.1016/j.bmcl.2006.09.028. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17005393
Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
Warshawsky AM, Alt CA, Brozinick JT, Harkness AR, Hawkins ED, Henry JR, Matthews DP, Miller AR, Misener EA, Montrose-Rafizadeh C, Rhodes GA, Shen Q, Vance JA, Udodong UE, Wang M, Zhang TY, Zink RW. Warshawsky AM, et al. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6328-33. doi: 10.1016/j.bmcl.2006.09.011. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17005394
A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia.
Reifel-Miller A, Otto K, Hawkins E, Barr R, Bensch WR, Bull C, Dana S, Klausing K, Martin JA, Rafaeloff-Phail R, Rafizadeh-Montrose C, Rhodes G, Robey R, Rojo I, Rungta D, Snyder D, Wilbur K, Zhang T, Zink R, Warshawsky A, Brozinick JT. Reifel-Miller A, et al. Mol Endocrinol. 2005 Jun;19(6):1593-605. doi: 10.1210/me.2005-0015. Epub 2005 Apr 14. Mol Endocrinol. 2005. PMID: 15831517
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.
Martín JA, Brooks DA, Prieto L, González R, Torrado A, Rojo I, López de Uralde B, Lamas C, Ferritto R, Dolores Martín-Ortega M, Agejas J, Parra F, Rizzo JR, Rhodes GA, Robey RL, Alt CA, Wendel SR, Zhang TY, Reifel-Miller A, Montrose-Rafizadeh C, Brozinick JT, Hawkins E, Misener EA, Briere DA, Ardecky R, Fraser JD, Warshawsky AM. Martín JA, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2005 Jan 3;15(1):51-5. doi: 10.1016/j.bmcl.2004.10.042. Bioorg Med Chem Lett. 2005. PMID: 15582409
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Brooks DA, Etgen GJ, Rito CJ, Shuker AJ, Dominianni SJ, Warshawsky AM, Ardecky R, Paterniti JR, Tyhonas J, Karanewsky DS, Kauffman RF, Broderick CL, Oldham BA, Montrose-Rafizadeh C, Winneroski LL, Faul MM, McCarthy JR. Brooks DA, et al. Among authors: warshawsky am. J Med Chem. 2001 Jun 21;44(13):2061-4. doi: 10.1021/jm0155188. J Med Chem. 2001. PMID: 11405642
Discovery and characterization of a potent and selective EP4 receptor antagonist.
Schiffler MA, Chandrasekhar S, Fisher MJ, Harvey A, Kuklish SL, Wang XS, Warshawsky AM, York JS, Yu XP. Schiffler MA, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3176-8. doi: 10.1016/j.bmcl.2015.05.091. Epub 2015 Jun 4. Bioorg Med Chem Lett. 2015. PMID: 26091726
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Blanco MJ, Vetman T, Chandrasekhar S, Fisher MJ, Harvey A, Chambers M, Lin C, Mudra D, Oskins J, Wang XS, Yu XP, Warshawsky AM. Blanco MJ, et al. Among authors: warshawsky am. Bioorg Med Chem Lett. 2016 Feb 1;26(3):931-935. doi: 10.1016/j.bmcl.2015.12.057. Epub 2015 Dec 25. Bioorg Med Chem Lett. 2016. PMID: 26764191
15 results