Dobbs N - Search Results

1

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.

Gonugunta VK, Sakai T, Pokatayev V, Yang K, Wu J, Dobbs N, Yan N. Gonugunta VK, et al. Among authors: dobbs n. Cell Rep. 2017 Dec 12;21(11):3234-3242. doi: 10.1016/j.celrep.2017.11.061. Cell Rep. 2017. PMID: 29241549 Free PMC article.

2

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.

Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N. Dobbs N, et al. Cell Host Microbe. 2015 Aug 12;18(2):157-68. doi: 10.1016/j.chom.2015.07.001. Epub 2015 Jul 30. Cell Host Microbe. 2015. PMID: 26235147 Free PMC article.

3

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice.

Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li QZ, Yan N. Hasan M, et al. Among authors: dobbs n. J Immunol. 2015 Nov 15;195(10):4573-7. doi: 10.4049/jimmunol.1500162. Epub 2015 Oct 2. J Immunol. 2015. PMID: 26432890 Free PMC article.

4

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.

Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N. Hasan M, et al. Among authors: dobbs n. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):746-751. doi: 10.1073/pnas.1611113114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069950 Free PMC article.

5

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1.

Aroh C, Wang Z, Dobbs N, Luo M, Chen Z, Gao J, Yan N. Aroh C, et al. Among authors: dobbs n. J Immunol. 2017 Dec 1;199(11):3840-3848. doi: 10.4049/jimmunol.1700972. Epub 2017 Oct 30. J Immunol. 2017. PMID: 29084836 Free PMC article.

6

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.

Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Wu J, et al. Among authors: dobbs n. J Exp Med. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192. Epub 2019 Mar 18. J Exp Med. 2019. PMID: 30886058 Free PMC article.

7

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.

Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N. Fermaintt CS, et al. Among authors: dobbs n. Nat Commun. 2019 May 30;10(1):2377. doi: 10.1038/s41467-019-10319-5. Nat Commun. 2019. PMID: 31147550 Free PMC article.

8

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.

Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N. Pokatayev V, et al. Among authors: dobbs n. Nat Immunol. 2020 Feb;21(2):158-167. doi: 10.1038/s41590-019-0569-9. Epub 2020 Jan 13. Nat Immunol. 2020. PMID: 31932809 Free PMC article.

9

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.

Wu J, Dobbs N, Yang K, Yan N. Wu J, et al. Among authors: dobbs n. Immunity. 2020 Jul 14;53(1):115-126.e5. doi: 10.1016/j.immuni.2020.06.009. Epub 2020 Jul 7. Immunity. 2020. PMID: 32640258 Free PMC article.

10

Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N. Tu X, et al. Among authors: dobbs n. Nat Commun. 2022 Nov 15;13(1):6977. doi: 10.1038/s41467-022-33765-0. Nat Commun. 2022. PMID: 36379959 Free PMC article.

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