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Page 1
Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue.
Saksis R, Silamikelis I, Laksa P, Megnis K, Peculis R, Mandrika I, Rogoza O, Petrovska R, Balcere I, Konrade I, Steina L, Stukens J, Breiksa A, Nazarovs J, Sokolovska J, Pirags V, Klovins J, Rovite V. Saksis R, et al. Among authors: silamikelis i. Front Oncol. 2021 Feb 15;10:593760. doi: 10.3389/fonc.2020.593760. eCollection 2020. Front Oncol. 2021. PMID: 33680922 Free PMC article.
Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance.
Brīvība M, Silamiķele L, Kalniņa I, Silamiķelis I, Birzniece L, Ansone L, Jagare L, Elbere I, Kloviņš J. Brīvība M, et al. Among authors: silamikelis i. Front Endocrinol (Lausanne). 2023 Sep 19;14:1232143. doi: 10.3389/fendo.2023.1232143. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37795356 Free PMC article.
Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.
Ustinova M, Silamikelis I, Kalnina I, Ansone L, Rovite V, Elbere I, Radovica-Spalvina I, Fridmanis D, Aladyeva J, Konrade I, Pirags V, Klovins J. Ustinova M, et al. Among authors: silamikelis i. PLoS One. 2019 Nov 8;14(11):e0224835. doi: 10.1371/journal.pone.0224835. eCollection 2019. PLoS One. 2019. PMID: 31703101 Free PMC article.
Case report: recurrent pituitary adenoma has increased load of somatic variants.
Peculis R, Balcere I, Radovica-Spalvina I, Konrade I, Caune O, Megnis K, Rovite V, Stukens J, Nazarovs J, Breiksa A, Kiecis A, Silamikelis I, Pirags V, Klovins J. Peculis R, et al. Among authors: silamikelis i. BMC Endocr Disord. 2020 Jan 29;20(1):17. doi: 10.1186/s12902-020-0493-x. BMC Endocr Disord. 2020. PMID: 31996211 Free PMC article.
Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.
Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J. Elbere I, et al. Among authors: silamikelis i. Clin Epigenetics. 2018 Dec 13;10(1):156. doi: 10.1186/s13148-018-0593-x. Clin Epigenetics. 2018. PMID: 30545422 Free PMC article. Clinical Trial.
Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.
Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J. Elbere I, et al. Among authors: silamikelis i. PLoS One. 2020 Oct 30;15(10):e0241338. doi: 10.1371/journal.pone.0241338. eCollection 2020. PLoS One. 2020. PMID: 33125401 Free PMC article.
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