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Page 1
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.
Terakado M, Suzuki H, Hashimura K, Tanaka M, Ueda H, Hirai K, Asada M, Ikura M, Matsunaga N, Saga H, Shinozaki K, Karakawa N, Takada Y, Minami M, Egashira H, Sugiura Y, Yamada M, Nakade S, Takaoka Y. Terakado M, et al. Among authors: takada y. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286. doi: 10.1021/acsmedchemlett.7b00383. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259748 Free PMC article.
Discovery of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Takada Y, Shioya H, Komiya T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: takada y. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3885-9. doi: 10.1016/j.bmcl.2011.05.029. Epub 2011 May 15. Bioorg Med Chem Lett. 2011. PMID: 21641216
Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Tokuda N, Takada Y, Shioya H, Mizuno H, Komiya T, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: takada y. Bioorg Med Chem Lett. 2012 Jan 1;22(1):144-8. doi: 10.1016/j.bmcl.2011.11.048. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22153936
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: takada y. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624
A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension.
Saga H, Ohhata A, Hayashi A, Katoh M, Maeda T, Mizuno H, Takada Y, Komichi Y, Ota H, Matsumura N, Shibaya M, Sugiyama T, Nakade S, Kishikawa K. Saga H, et al. Among authors: takada y. PLoS One. 2014 Apr 18;9(4):e93230. doi: 10.1371/journal.pone.0093230. eCollection 2014. PLoS One. 2014. PMID: 24747415 Free PMC article.
Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis.
Komiya T, Sato K, Shioya H, Inagaki Y, Hagiya H, Kozaki R, Imai M, Takada Y, Maeda T, Kurata H, Kurono M, Suzuki R, Otsuki K, Habashita H, Nakade S. Komiya T, et al. Among authors: takada y. Clin Exp Immunol. 2013 Jan;171(1):54-62. doi: 10.1111/j.1365-2249.2012.04669.x. Clin Exp Immunol. 2013. PMID: 23199323 Free PMC article.
Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study.
Takada Y, Kiyohara H, Mikami Y, Taguri M, Sakakibara R, Aoki Y, Nanki K, Kawaguchi T, Yoshimatsu Y, Sugimoto S, Sujino T, Takabayashi K, Hosoe N, Ogata H, Kato M, Iwao Y, Nakamoto N, Kanai T. Takada Y, et al. Ann Med. 2025 Dec;57(1):2453083. doi: 10.1080/07853890.2025.2453083. Epub 2025 Jan 17. Ann Med. 2025. PMID: 39823192 Free PMC article.
Endoscopic incisional balloon dilation combined with anti-scarring agents for postoperative esophageal anastomotic strictures.
Kumagai K, Takada Y, Sugimoto A, Sakagami S, Akioka Y, Mitani R, Oshima A, Kitade M, Oshiro M, Katsuyama S, Ota S, Adachi K, Shimada Y, Hayashi M, Itami A, Itani T. Kumagai K, et al. Among authors: takada y. DEN Open. 2025 Jan 16;5(1):e70062. doi: 10.1002/deo2.70062. eCollection 2025 Apr. DEN Open. 2025. PMID: 39822949 Free PMC article.
1,866 results