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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA. Wang C, et al. Among authors: douglas pm. Nat Commun. 2017 Dec 22;8(1):2270. doi: 10.1038/s41467-017-02332-3. Nat Commun. 2017. PMID: 29273768 Free PMC article.
Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA. Wang C, et al. Among authors: douglas pm. Nat Commun. 2018 May 21;9(1):2050. doi: 10.1038/s41467-018-04519-8. Nat Commun. 2018. PMID: 29784984 Free PMC article.
Intracellular lipid surveillance by small G protein geranylgeranylation.
Watterson A, Tatge L, Wajahat N, Arneaud SLB, Solano Fonseca R, Beheshti ST, Metang P, Mihelakis M, Zuurbier KR, Corley CD, Dehghan I, McDonald JG, Douglas PM. Watterson A, et al. Among authors: douglas pm. Nature. 2022 May;605(7911):736-740. doi: 10.1038/s41586-022-04729-7. Epub 2022 May 18. Nature. 2022. PMID: 35585236 Free PMC article.
The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
Das R, Melo JA, Thondamal M, Morton EA, Cornwell AB, Crick B, Kim JH, Swartz EW, Lamitina T, Douglas PM, Samuelson AV. Das R, et al. Among authors: douglas pm. PLoS Genet. 2017 Oct 16;13(10):e1007038. doi: 10.1371/journal.pgen.1007038. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 29036198 Free PMC article.
A framework for intestinal barrier dysfunction in aging.
Tatge L, Solano Fonseca R, Douglas PM. Tatge L, et al. Among authors: douglas pm. Nat Aging. 2023 Oct;3(10):1172-1174. doi: 10.1038/s43587-023-00492-0. Nat Aging. 2023. PMID: 37723210 No abstract available.
33 results