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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA. Wang C, et al. Among authors: macmillan jb. Nat Commun. 2017 Dec 22;8(1):2270. doi: 10.1038/s41467-017-02332-3. Nat Commun. 2017. PMID: 29273768 Free PMC article.
Towards patient-based cancer therapeutics.
Cancer Target Discovery and Development Network; Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA. Cancer Target Discovery and Development Network, et al. Among authors: macmillan jb. Nat Biotechnol. 2010 Sep;28(9):904-6. doi: 10.1038/nbt0910-904. Nat Biotechnol. 2010. PMID: 20829823 Free PMC article.
Chromomycin SA analogs from a marine-derived Streptomyces sp.
Hu Y, Espindola AP, Stewart NA, Wei S, Posner BA, MacMillan JB. Hu Y, et al. Among authors: macmillan jb. Bioorg Med Chem. 2011 Sep 1;19(17):5183-9. doi: 10.1016/j.bmc.2011.07.013. Epub 2011 Jul 20. Bioorg Med Chem. 2011. PMID: 21807523 Free PMC article.
AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.
Fisher KW, Das B, Kim HS, Clymer BK, Gehring D, Smith DR, Costanzo-Garvey DL, Fernandez MR, Brattain MG, Kelly DL, MacMillan J, White MA, Lewis RE. Fisher KW, et al. Mol Cell Biol. 2015 Nov;35(22):3866-79. doi: 10.1128/MCB.00528-15. Epub 2015 Sep 8. Mol Cell Biol. 2015. PMID: 26351140 Free PMC article.
100 results