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Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Yang XH, et al. Among authors: moskowitz ip. Elife. 2017 Dec 27;6:e31683. doi: 10.7554/eLife.31683. Elife. 2017. PMID: 29280435 Free PMC article.
TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP. Arnolds DE, et al. Among authors: moskowitz ip. J Clin Invest. 2012 Jul;122(7):2509-18. doi: 10.1172/JCI62617. Epub 2012 Jun 25. J Clin Invest. 2012. PMID: 22728936 Free PMC article.
A common genetic variant within SCN10A modulates cardiac SCN5A expression.
van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP. van den Boogaard M, et al. Among authors: moskowitz ip. J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18. J Clin Invest. 2014. PMID: 24642470 Free PMC article.
Many ways to break a heart.
Rowton M, Moskowitz IP. Rowton M, et al. Among authors: moskowitz ip. Elife. 2015 Aug 25;4:e10040. doi: 10.7554/eLife.10040. Elife. 2015. PMID: 26305497 Free PMC article.
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP. Burnicka-Turek O, et al. Among authors: moskowitz ip. Hum Mol Genet. 2016 Jul 15;25(14):3011-3028. doi: 10.1093/hmg/ddw155. Epub 2016 Jun 23. Hum Mol Genet. 2016. PMID: 27340223 Free PMC article.
Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP. Nadadur RD, et al. Among authors: moskowitz ip. Sci Transl Med. 2016 Aug 31;8(354):354ra115. doi: 10.1126/scitranslmed.aaf4891. Sci Transl Med. 2016. PMID: 27582060 Free PMC article.
87 results