Humphries PS - Search Results

1

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E. Humphries PS, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):293-297. doi: 10.1016/j.bmcl.2017.12.051. Epub 2017 Dec 24. Bioorg Med Chem Lett. 2018. PMID: 29292223

2

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E. Humphries PS, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):757-760. doi: 10.1016/j.bmcl.2015.12.102. Epub 2015 Dec 30. Bioorg Med Chem Lett. 2016. PMID: 26778255

3

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Bailey S, Almaden JV, Barnum SJ, Carlson TJ, Christie LC, Do QQ, Fraser JD, Hess M, Kellum J, Kim YH, McClellan GA, Ogilvie KM, Simmons BH, Skalitzky D, Sun S, Wilhite D, Zehnder LR. Humphries PS, et al. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6120-3. doi: 10.1016/j.bmcl.2006.08.110. Epub 2006 Sep 14. Bioorg Med Chem Lett. 2006. PMID: 16973358

4

Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Humphries PS, Almaden JV, Barnum SJ, Carlson TJ, Do QQ, Fraser JD, Hess M, Kim YH, Ogilvie KM, Sun S. Humphries PS, et al. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6116-9. doi: 10.1016/j.bmcl.2006.08.105. Epub 2006 Sep 18. Bioorg Med Chem Lett. 2006. PMID: 16979341

5

Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.

Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS. Black SW, et al. Among authors: humphries ps. Sleep. 2018 Sep 1;41(9). doi: 10.1093/sleep/zsy116. Sleep. 2018. PMID: 29860347

6

Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Humphries PS, Lafontaine JA, Agree CS, Alexander D, Chen P, Do QQ, Li LY, Lunney EA, Rajapakse RJ, Siegel K, Timofeevski SL, Wang T, Wilhite DM. Humphries PS, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2099-102. doi: 10.1016/j.bmcl.2009.03.023. Epub 2009 Mar 13. Bioorg Med Chem Lett. 2009. PMID: 19327989

7

Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.

Guo C, Hou X, Dong L, Marakovits J, Greasley S, Dagostino E, Ferre R, Johnson MC, Humphries PS, Li H, Paderes GD, Piraino J, Kraynov E, Murray BW. Guo C, et al. Among authors: humphries ps. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4187-91. doi: 10.1016/j.bmcl.2014.07.044. Epub 2014 Jul 22. Bioorg Med Chem Lett. 2014. PMID: 25091930

8

Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.

Kabeche S, Aida J, Akther T, Ichikawa T, Ochida A, Pulkoski-Gross MJ, Smith M, Humphries PS, Yeh E. Kabeche S, et al. Among authors: humphries ps. Bioorg Med Chem Lett. 2021 Jun 1;41:127978. doi: 10.1016/j.bmcl.2021.127978. Epub 2021 Mar 22. Bioorg Med Chem Lett. 2021. PMID: 33766764

9

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.

Humphries PS, Benbow JW, Bonin PD, Boyer D, Doran SD, Frisbie RK, Piotrowski DW, Balan G, Bechle BM, Conn EL, Dirico KJ, Oliver RM, Soeller WC, Southers JA, Yang X. Humphries PS, et al. Bioorg Med Chem Lett. 2009 May 1;19(9):2400-3. doi: 10.1016/j.bmcl.2009.03.082. Epub 2009 Mar 25. Bioorg Med Chem Lett. 2009. PMID: 19346127

10

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.

Filipski KJ, Guzman-Perez A, Bian J, Perreault C, Aspnes GE, Didiuk MT, Dow RL, Hank RF, Jones CS, Maguire RJ, Tu M, Zeng D, Liu S, Knafels JD, Litchfield J, Atkinson K, Derksen DR, Bourbonais F, Gajiwala KS, Hickey M, Johnson TO, Humphries PS, Pfefferkorn JA. Filipski KJ, et al. Among authors: humphries ps. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4571-8. doi: 10.1016/j.bmcl.2013.06.036. Epub 2013 Jun 20. Bioorg Med Chem Lett. 2013. PMID: 23831135

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