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Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
Wei ZL, Nguyen MT, O'Mahony DJ, Acevedo A, Zipfel S, Zhang Q, Liu L, Dourado M, Chi C, Yip V, DeFalco J, Gustafson A, Emerling DE, Kelly MG, Kincaid J, Vincent F, Duncton MA. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5. doi: 10.1016/j.bmcl.2015.06.098. Epub 2015 Jul 6. Bioorg Med Chem Lett. 2015. PMID: 26235950
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications.
Nerurkar A, Nguyen T, Wang S, Bhatt U, Li K, Li Y, Ding P, Seidl FJ, Holan M, Lee J, Widjaja T, Wei ZL, Sadlowski C, Sperandio D, McGee LR, Youngblood B, Schwartz N, Gehlert D, Medina JC. Nerurkar A, et al. Among authors: wei zl. Bioorg Med Chem Lett. 2023 Aug 15;92:129405. doi: 10.1016/j.bmcl.2023.129405. Epub 2023 Jul 5. Bioorg Med Chem Lett. 2023. PMID: 37414346 Free PMC article.
NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
Shi LY, Wang Y, Yang YJ, Li Q, Yang ZX, Sun LH, Luo FQ, He YH, Zhang SP, Su N, Liu JQ, He Y, Guan YC, Wei ZL, Cao YX, Zhang D. Shi LY, et al. Among authors: wei zl. Cell Mol Biol Lett. 2024 May 10;29(1):68. doi: 10.1186/s11658-024-00580-y. Cell Mol Biol Lett. 2024. PMID: 38730334 Free PMC article.
136 results