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Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB).
Azpilikueta A, Bolaños E, Lang V, Labiano S, Aznar MA, Etxeberria I, Teijeira A, Rodriguez-Ruiz ME, Perez-Gracia JL, Jure-Kunkel M, Zapata JM, Rodriguez MS, Melero I. Azpilikueta A, et al. Among authors: zapata jm. Oncoimmunology. 2017 Sep 21;7(1):e1368605. doi: 10.1080/2162402X.2017.1368605. eCollection 2017. Oncoimmunology. 2017. PMID: 29296520 Free PMC article.
T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.
Martinez-Forero I, Azpilikueta A, Bolaños-Mateo E, Nistal-Villan E, Palazon A, Teijeira A, Perez-Chacon G, Morales-Kastresana A, Murillo O, Jure-Kunkel M, Zapata JM, Melero I. Martinez-Forero I, et al. Among authors: zapata jm. J Immunol. 2013 Jun 15;190(12):6694-706. doi: 10.4049/jimmunol.1203010. Epub 2013 May 20. J Immunol. 2013. PMID: 23690480
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs.
Zapata JM, Perez-Chacon G, Carr-Baena P, Martinez-Forero I, Azpilikueta A, Otano I, Melero I. Zapata JM, et al. Front Immunol. 2018 Nov 15;9:2618. doi: 10.3389/fimmu.2018.02618. eCollection 2018. Front Immunol. 2018. PMID: 30524423 Free PMC article. Review.
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L. Compte M, et al. Among authors: zapata jm. Nat Commun. 2018 Nov 15;9(1):4809. doi: 10.1038/s41467-018-07195-w. Nat Commun. 2018. PMID: 30442944 Free PMC article.
Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR.
Compte M, Harwood SL, Martínez-Torrecuadrada J, Perez-Chacon G, González-García P, Tapia-Galisteo A, Van Bergen En Henegouwen PMP, Sánchez A, Fabregat I, Sanz L, Zapata JM, Alvarez-Vallina L. Compte M, et al. Among authors: zapata jm. Front Immunol. 2021 Jan 7;11:614363. doi: 10.3389/fimmu.2020.614363. eCollection 2020. Front Immunol. 2021. PMID: 33488625 Free PMC article.
Editorial: Mouse Models of B Cell Malignancies.
Perez-Chacon G, Vincent-Fabert C, Zapata JM. Perez-Chacon G, et al. Among authors: zapata jm. Front Immunol. 2021 Oct 28;12:789901. doi: 10.3389/fimmu.2021.789901. eCollection 2021. Front Immunol. 2021. PMID: 34777400 Free PMC article. No abstract available.
Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy.
Garaulet G, Pérez-Chacon G, Alarcón H, Alfranca A, Mulero F, Martínez-Torrecuadrada J, Zapata JM, Rodríguez A. Garaulet G, et al. Among authors: zapata jm. Cancer Gene Ther. 2019 Jul;26(7-8):216-233. doi: 10.1038/s41417-018-0076-4. Epub 2019 Jan 9. Cancer Gene Ther. 2019. PMID: 30622324 Free article.
99 results