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Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, Brown MF, Flanagan ME, Mitton-Fry MJ, Johnson TA, TenBrink RE, Arnold EP, Basak A, Heasley SE, Kwon S, Langille J, Parikh MD, Griffin SH, Casavant JM, Duclos BA, Fenwick AE, Harris TM, Han S, Caspers N, Dowty ME, Yang X, Banker ME, Hegen M, Symanowicz PT, Li L, Wang L, Lin TH, Jussif J, Clark JD, Telliez JB, Robinson RP, Unwalla R. Vazquez ML, et al. Among authors: duclos ba. J Med Chem. 2018 Feb 8;61(3):1130-1152. doi: 10.1021/acs.jmedchem.7b01598. Epub 2018 Jan 23. J Med Chem. 2018. PMID: 29298069
In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain.
Subramanian G, Duclos B, Johnson PD, Williams T, Ross JT, Bowen SJ, Zhu Y, White JA, Hedke C, Huczek D, Collard W, Javens C, Vairagoundar R, Respondek T, Zachary T, Maddux T, Cox MR, Kamerling S, Gonzales AJ. Subramanian G, et al. ACS Med Chem Lett. 2021 Oct 25;12(11):1847-1852. doi: 10.1021/acsmedchemlett.1c00483. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795875 Free PMC article.