Reverter D - Search Results

1

Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.

Varejão N, De-Andrade RA, Almeida RV, Anobom CD, Foguel D, Reverter D. Varejão N, et al. Among authors: reverter d. Structure. 2018 Feb 6;26(2):199-208.e3. doi: 10.1016/j.str.2017.12.004. Epub 2018 Jan 4. Structure. 2018. PMID: 29307486 Free article.

2

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.

Sant'Anna R, Almeida MR, Varejāo N, Gallego P, Esperante S, Ferreira P, Pereira-Henriques A, Palhano FL, de Carvalho M, Foguel D, Reverter D, Saraiva MJ, Ventura S. Sant'Anna R, et al. Among authors: reverter d. Sci Rep. 2017 Mar 24;7:44709. doi: 10.1038/srep44709. Sci Rep. 2017. PMID: 28338000 Free PMC article.

3

DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex.

Varejão N, Ibars E, Lascorz J, Colomina N, Torres-Rosell J, Reverter D. Varejão N, et al. Among authors: reverter d. EMBO J. 2018 Jun 15;37(12):e98306. doi: 10.15252/embj.201798306. Epub 2018 May 16. EMBO J. 2018. PMID: 29769404 Free PMC article.

4

Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.

Gil-Garcia M, Bañó-Polo M, Varejão N, Jamroz M, Kuriata A, Díaz-Caballero M, Lascorz J, Morel B, Navarro S, Reverter D, Kmiecik S, Ventura S. Gil-Garcia M, et al. Among authors: reverter d. Mol Pharm. 2018 Sep 4;15(9):3846-3859. doi: 10.1021/acs.molpharmaceut.8b00341. Epub 2018 Aug 6. Mol Pharm. 2018. PMID: 30036481

5

Molecular mechanisms in SUMO conjugation.

Varejão N, Lascorz J, Li Y, Reverter D. Varejão N, et al. Among authors: reverter d. Biochem Soc Trans. 2020 Feb 28;48(1):123-135. doi: 10.1042/BST20190357. Biochem Soc Trans. 2020. PMID: 31872228 Review.

6

Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.

Pinheiro F, Varejão N, Esperante S, Santos J, Velázquez-Campoy A, Reverter D, Pallarès I, Ventura S. Pinheiro F, et al. Among authors: reverter d. FEBS J. 2021 Jan;288(1):310-324. doi: 10.1111/febs.15339. Epub 2020 May 11. FEBS J. 2021. PMID: 32324953 Free article.

7

Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.

Esperante SA, Varejāo N, Pinheiro F, Sant'Anna R, Luque-Ortega JR, Alfonso C, Sora V, Papaleo E, Rivas G, Reverter D, Ventura S. Esperante SA, et al. Among authors: reverter d. J Biol Chem. 2021 Sep;297(3):101039. doi: 10.1016/j.jbc.2021.101039. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343569 Free PMC article.

8

Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.

Varejão N, Lascorz J, Codina-Fabra J, Bellí G, Borràs-Gas H, Torres-Rosell J, Reverter D. Varejão N, et al. Among authors: reverter d. Nat Commun. 2021 Dec 1;12(1):7013. doi: 10.1038/s41467-021-27301-9. Nat Commun. 2021. PMID: 34853311 Free PMC article.

9

Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.

Li Y, Varejão N, Reverter D. Li Y, et al. Among authors: reverter d. Nat Commun. 2022 Apr 5;13(1):1819. doi: 10.1038/s41467-022-29485-0. Nat Commun. 2022. PMID: 35383180 Free PMC article.

10

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.

Pinheiro F, Pallarès I, Peccati F, Sánchez-Morales A, Varejão N, Bezerra F, Ortega-Alarcon D, Gonzalez D, Osorio M, Navarro S, Velázquez-Campoy A, Almeida MR, Reverter D, Busqué F, Alibés R, Sodupe M, Ventura S. Pinheiro F, et al. Among authors: reverter d. J Med Chem. 2022 Nov 10;65(21):14673-14691. doi: 10.1021/acs.jmedchem.2c01195. Epub 2022 Oct 28. J Med Chem. 2022. PMID: 36306808 Free PMC article.

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