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Page 1
18O-Enabled High-Throughput Acyl Glucuronide Stability Assay.
Yu ZJ, Le H, Tang J, Yue Q, Zhang J, Murray B, Liu X, Smith BJ, Subramanian R. Yu ZJ, et al. Among authors: subramanian r. Chem Res Toxicol. 2022 Aug 15;35(8):1400-1409. doi: 10.1021/acs.chemrestox.2c00156. Epub 2022 Jul 14. Chem Res Toxicol. 2022. PMID: 35833852
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
Li R, Liclican A, Xu Y, Pitts J, Niu C, Zhang J, Kim C, Zhao X, Soohoo D, Babusis D, Yue Q, Ma B, Murray BP, Subramanian R, Xie X, Zou J, Bilello JP, Li L, Schultz BE, Sakowicz R, Smith BJ, Shi PY, Murakami E, Feng JY. Li R, et al. Among authors: subramanian r. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0060221. doi: 10.1128/AAC.00602-21. Epub 2021 Aug 17. Antimicrob Agents Chemother. 2021. PMID: 34125594 Free PMC article.
Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).
Subramanian R, Zhu X, Kerr SJ, Esmay JD, Louie SW, Edson KZ, Walter S, Fitzsimmons M, Wagner M, Soto M, Pham R, Wilson SF, Skiles GL. Subramanian R, et al. Drug Metab Dispos. 2016 Aug;44(8):1319-31. doi: 10.1124/dmd.115.068007. Epub 2016 Feb 19. Drug Metab Dispos. 2016. PMID: 26895981
Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.
Pitts J, Babusis D, Vermillion MS, Subramanian R, Barrett K, Lye D, Ma B, Zhao X, Riola N, Xie X, Kajon A, Lu X, Bannister R, Shi PY, Toteva M, Porter DP, Smith BJ, Cihlar T, Mackman R, Bilello JP. Pitts J, et al. Among authors: subramanian r. Antiviral Res. 2022 Jul;203:105329. doi: 10.1016/j.antiviral.2022.105329. Epub 2022 May 5. Antiviral Res. 2022. PMID: 35525335 Free PMC article.
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.
Vermillion MS, Murakami E, Ma B, Pitts J, Tomkinson A, Rautiola D, Babusis D, Irshad H, Seigel D, Kim C, Zhao X, Niu C, Yang J, Gigliotti A, Kadrichu N, Bilello JP, Ellis S, Bannister R, Subramanian R, Smith B, Mackman RL, Lee WA, Kuehl PJ, Hartke J, Cihlar T, Porter DP. Vermillion MS, et al. Among authors: subramanian r. Sci Transl Med. 2022 Feb 23;14(633):eabl8282. doi: 10.1126/scitranslmed.abl8282. Epub 2022 Feb 23. Sci Transl Med. 2022. PMID: 34968150 Free PMC article.
Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity.
Gibson CR, Lin C, Singh R, Brown CM, Richards K, Brunner J, Michel K, Adelsberger J, Carlini E, Boothe-Genthe C, Raab C, Luu M, Michael A, Parikh M, Ciecko P, Subramanian R, Krolikowski P, Rodrigues AD, Baillie TA, Rushmore TH. Gibson CR, et al. Among authors: subramanian r. Drug Metab Dispos. 2005 Jul;33(7):1044-51. doi: 10.1124/dmd.105.003913. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833927
Metabolism and disposition of a potent and selective GABA-Aalpha2/3 receptor agonist in healthy male volunteers.
Polsky-Fisher SL, Vickers S, Cui D, Subramanian R, Arison BH, Agrawal NG, Goel TV, Vessey LK, Murphy MG, Lasseter KC, Simpson RC, Vega JM, Rodrigues AD. Polsky-Fisher SL, et al. Among authors: subramanian r. Drug Metab Dispos. 2006 Jun;34(6):1004-11. doi: 10.1124/dmd.105.008193. Epub 2006 Mar 1. Drug Metab Dispos. 2006. PMID: 16510541 Clinical Trial.
760 results