Faltynek CR - Search Results

1

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.

Judge RA, Vasudevan A, Scott VE, Simler GH, Pratt SD, Namovic MT, Putman CB, Aguirre A, Stoll VS, Mamo M, Swann SI, Cassar SC, Faltynek CR, Kage KL, Boyce-Rustay JM, Hobson AD. Judge RA, et al. Among authors: faltynek cr. Chembiochem. 2018 Mar 16;19(6):613-621. doi: 10.1002/cbic.201700547. Epub 2018 Jan 30. Chembiochem. 2018. PMID: 29314498

2

Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells.

Donnelly-Roberts DL, Namovic MT, Faltynek CR, Jarvis MF. Donnelly-Roberts DL, et al. Among authors: faltynek cr. J Pharmacol Exp Ther. 2004 Mar;308(3):1053-61. doi: 10.1124/jpet.103.059600. Epub 2003 Nov 21. J Pharmacol Exp Ther. 2004. PMID: 14634045

3

Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists.

Nelson DW, Sarris K, Kalvin DM, Namovic MT, Grayson G, Donnelly-Roberts DL, Harris R, Honore P, Jarvis MF, Faltynek CR, Carroll WA. Nelson DW, et al. Among authors: faltynek cr. J Med Chem. 2008 May 22;51(10):3030-4. doi: 10.1021/jm701516f. Epub 2008 Apr 26. J Med Chem. 2008. PMID: 18438986

4

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.

Perez-Medrano A, Donnelly-Roberts DL, Florjancic AS, Nelson DW, Li T, Namovic MT, Peddi S, Faltynek CR, Jarvis MF, Carroll WA. Perez-Medrano A, et al. Among authors: faltynek cr. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3297-300. doi: 10.1016/j.bmcl.2011.04.024. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536435

5

Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk- cells.

Malysz J, Scott VE, Faltynek C, Gopalakrishnan M. Malysz J, et al. Life Sci. 2008 Jan 2;82(1-2):30-40. doi: 10.1016/j.lfs.2007.10.008. Epub 2007 Oct 26. Life Sci. 2008. PMID: 18054963

6

Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists.

Chen J, Lake MR, Sabet RS, Niforatos W, Pratt SD, Cassar SC, Xu J, Gopalakrishnan S, Pereda-Lopez A, Gopalakrishnan M, Holzman TF, Moreland RB, Walter KA, Faltynek CR, Warrior U, Scott VE. Chen J, et al. Among authors: faltynek cr. J Biomol Screen. 2007 Feb;12(1):61-9. doi: 10.1177/1087057106295220. Epub 2006 Nov 12. J Biomol Screen. 2007. PMID: 17099245

7

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

Nelson DW, Gregg RJ, Kort ME, Perez-Medrano A, Voight EA, Wang Y, Grayson G, Namovic MT, Donnelly-Roberts DL, Niforatos W, Honore P, Jarvis MF, Faltynek CR, Carroll WA. Nelson DW, et al. Among authors: faltynek cr. J Med Chem. 2006 Jun 15;49(12):3659-66. doi: 10.1021/jm051202e. J Med Chem. 2006. PMID: 16759108

8

Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.

Davis-Taber R, Baker S, Lehto SG, Zhong C, Surowy CS, Faltynek CR, Scott VE, Honore P. Davis-Taber R, et al. Among authors: faltynek cr. J Pain. 2008 May;9(5):449-56. doi: 10.1016/j.jpain.2008.01.329. Epub 2008 Mar 12. J Pain. 2008. PMID: 18337184 Free article.

9

Molecular determinants of species-specific activation or blockade of TRPA1 channels.

Chen J, Zhang XF, Kort ME, Huth JR, Sun C, Miesbauer LJ, Cassar SC, Neelands T, Scott VE, Moreland RB, Reilly RM, Hajduk PJ, Kym PR, Hutchins CW, Faltynek CR. Chen J, et al. Among authors: faltynek cr. J Neurosci. 2008 May 7;28(19):5063-71. doi: 10.1523/JNEUROSCI.0047-08.2008. J Neurosci. 2008. PMID: 18463259 Free PMC article.

10

Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.

Perez-Medrano A, Donnelly-Roberts DL, Honore P, Hsieh GC, Namovic MT, Peddi S, Shuai Q, Wang Y, Faltynek CR, Jarvis MF, Carroll WA. Perez-Medrano A, et al. Among authors: faltynek cr. J Med Chem. 2009 May 28;52(10):3366-76. doi: 10.1021/jm8015848. J Med Chem. 2009. PMID: 19397270

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