Cai Z - Search Results

1

Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.

Liu J, Bihler H, Farinha CM, Awatade NT, Romão AM, Mercadante D, Cheng Y, Musisi I, Jantarajit W, Wang Y, Cai Z, Amaral MD, Mense M, Sheppard DN. Liu J, et al. Among authors: cai z. Br J Pharmacol. 2018 Apr;175(7):1017-1038. doi: 10.1111/bph.14141. Epub 2018 Feb 22. Br J Pharmacol. 2018. PMID: 29318594 Free PMC article.

2

Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.

Cai ZW, Liu J, Li HY, Sheppard DN. Cai ZW, et al. Acta Pharmacol Sin. 2011 Jun;32(6):693-701. doi: 10.1038/aps.2011.71. Acta Pharmacol Sin. 2011. PMID: 21642944 Free PMC article. Review.

3

Phloxine B interacts with the cystic fibrosis transmembrane conductance regulator at multiple sites to modulate channel activity.

Cai Z, Sheppard DN. Cai Z, et al. J Biol Chem. 2002 May 31;277(22):19546-53. doi: 10.1074/jbc.M108023200. Epub 2002 Mar 19. J Biol Chem. 2002. PMID: 11904291 Free article.

4

Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.

Cai Z, Scott-Ward TS, Sheppard DN. Cai Z, et al. J Gen Physiol. 2003 Nov;122(5):605-20. doi: 10.1085/jgp.200308921. J Gen Physiol. 2003. PMID: 14581585 Free PMC article.

5

Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

Cai Z, Taddei A, Sheppard DN. Cai Z, et al. J Biol Chem. 2006 Jan 27;281(4):1970-7. doi: 10.1074/jbc.M510576200. Epub 2005 Nov 25. J Biol Chem. 2006. PMID: 16311240 Free article.

6

Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation.

Pissarra LS, Farinha CM, Xu Z, Schmidt A, Thibodeau PH, Cai Z, Thomas PJ, Sheppard DN, Amaral MD. Pissarra LS, et al. Among authors: cai z. Chem Biol. 2008 Jan;15(1):62-9. doi: 10.1016/j.chembiol.2007.11.012. Chem Biol. 2008. PMID: 18215773

7

Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

Chen JH, Cai Z, Sheppard DN. Chen JH, et al. Among authors: cai z. J Biol Chem. 2009 Dec 18;284(51):35495-506. doi: 10.1074/jbc.M109.072678. J Biol Chem. 2009. PMID: 19837660 Free PMC article.

8

Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.

Cai Z, Sohma Y, Bompadre SG, Sheppard DN, Hwang TC. Cai Z, et al. Methods Mol Biol. 2011;741:419-41. doi: 10.1007/978-1-61779-117-8_27. Methods Mol Biol. 2011. PMID: 21594800 Free PMC article.

9

Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.

Cai Z, Li H, Chen JH, Sheppard DN. Cai Z, et al. Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C817-28. doi: 10.1152/ajpcell.00052.2013. Epub 2013 Jun 19. Am J Physiol Cell Physiol. 2013. PMID: 23784545 Free PMC article.

10

Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics.

Ju M, Scott-Ward TS, Liu J, Khuituan P, Li H, Cai Z, Husbands SM, Sheppard DN. Ju M, et al. Among authors: cai z. Br J Pharmacol. 2014 Jan;171(1):265-78. doi: 10.1111/bph.12458. Br J Pharmacol. 2014. PMID: 24117047 Free PMC article.

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