Wang Y - Search Results

1

Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.

Liu J, Bihler H, Farinha CM, Awatade NT, Romão AM, Mercadante D, Cheng Y, Musisi I, Jantarajit W, Wang Y, Cai Z, Amaral MD, Mense M, Sheppard DN. Liu J, et al. Among authors: wang y. Br J Pharmacol. 2018 Apr;175(7):1017-1038. doi: 10.1111/bph.14141. Epub 2018 Feb 22. Br J Pharmacol. 2018. PMID: 29318594 Free PMC article.

2

Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models.

Wang Y, Wrennall JA, Cai Z, Li H, Sheppard DN. Wang Y, et al. Int J Biochem Cell Biol. 2014 Jul;52:47-57. doi: 10.1016/j.biocel.2014.04.001. Epub 2014 Apr 13. Int J Biochem Cell Biol. 2014. PMID: 24727426 Review.

3

CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR.

Wang Y, Liu J, Loizidou A, Bugeja LA, Warner R, Hawley BR, Cai Z, Toye AM, Sheppard DN, Li H. Wang Y, et al. Br J Pharmacol. 2014 Oct;171(19):4490-503. doi: 10.1111/bph.12791. Epub 2014 Sep 5. Br J Pharmacol. 2014. PMID: 24902474 Free PMC article.

4

Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation.

Meng X, Wang Y, Wang X, Wrennall JA, Rimington TL, Li H, Cai Z, Ford RC, Sheppard DN. Meng X, et al. Among authors: wang x, wang y. J Biol Chem. 2017 Mar 3;292(9):3706-3719. doi: 10.1074/jbc.M116.751537. Epub 2017 Jan 13. J Biol Chem. 2017. PMID: 28087700 Free PMC article.

5

Potentiation of the cystic fibrosis transmembrane conductance regulator Cl^- channel by ivacaftor is temperature independent.

Wang Y, Cai Z, Gosling M, Sheppard DN. Wang Y, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L846-L857. doi: 10.1152/ajplung.00235.2018. Epub 2018 Aug 23. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 30136610 Free article.

6

Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR.

Bose SJ, Bijvelds MJC, Wang Y, Liu J, Cai Z, Bot AGM, de Jonge HR, Sheppard DN. Bose SJ, et al. Among authors: wang y. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L71-L86. doi: 10.1152/ajplung.00034.2019. Epub 2019 Apr 10. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30969810 Free PMC article.

7

A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

Liu J, Berg AP, Wang Y, Jantarajit W, Sutcliffe KJ, Stevens EB, Cao L, Pregel MJ, Sheppard DN. Liu J, et al. Among authors: wang y. Br J Pharmacol. 2022 Apr;179(7):1319-1337. doi: 10.1111/bph.15709. Epub 2022 Jan 21. Br J Pharmacol. 2022. PMID: 34644413 Free PMC article.

8

Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors.

Saint-Criq V, Wang Y, Delpiano L, Lin J, Sheppard DN, Gray MA. Saint-Criq V, et al. Among authors: wang y. J Cyst Fibros. 2021 Sep;20(5):843-850. doi: 10.1016/j.jcf.2021.04.013. Epub 2021 May 18. J Cyst Fibros. 2021. PMID: 34020896 Free PMC article.

9

A topological switch in CFTR modulates channel activity and sensitivity to unfolding.

Scholl D, Sigoillot M, Overtus M, Martinez RC, Martens C, Wang Y, Pardon E, Laeremans T, Garcia-Pino A, Steyaert J, Sheppard DN, Hendrix J, Govaerts C. Scholl D, et al. Among authors: wang y. Nat Chem Biol. 2021 Sep;17(9):989-997. doi: 10.1038/s41589-021-00844-0. Epub 2021 Aug 2. Nat Chem Biol. 2021. PMID: 34341587

10

CFTR bearing variant p.Phe312del exhibits function inconsistent with phenotype and negligible response to ivacaftor.

Raraigh KS, Paul KC, Goralski JL, Worthington EN, Faino AV, Sciortino S, Wang Y, Aksit MA, Ling H, Osorio DL, Onchiri FM, Patel SU, Merlo CA, Montemayor K, Gibson RL, West NE, Thakerar A, Bridges RJ, Sheppard DN, Sharma N, Cutting GR. Raraigh KS, et al. Among authors: wang y. JCI Insight. 2022 Mar 22;7(6):e148841. doi: 10.1172/jci.insight.148841. JCI Insight. 2022. PMID: 35315358 Free PMC article.

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