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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.
Williams WA, Linley JE, Jones CA, Shibata Y, Snijder A, Button J, Hatcher JP, Huang L, Taddese B, Thornton P, Schofield DJ, Thom G, Popovic B, Dosanjh B, Wilkinson T, Hughes J, Dobson CL, Groves MA, Webster CI, Billinton A, Vaughan TJ, Chessell I. Williams WA, et al. Among authors: hatcher jp. Pain. 2019 Sep;160(9):1989-2003. doi: 10.1097/j.pain.0000000000001587. Pain. 2019. PMID: 31045747
A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.
Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ, Abraham T, Jefferies WA, Webster CI, Gabathuler R. Thom G, et al. Among authors: hatcher jp. J Cereb Blood Flow Metab. 2019 Oct;39(10):2074-2088. doi: 10.1177/0271678X18772998. Epub 2018 May 30. J Cereb Blood Flow Metab. 2019. PMID: 29845881 Free PMC article.
Biologic drugs for analgesia: redefining the opportunity.
Hughes J, Hatcher JP, Chessell IP. Hughes J, et al. Among authors: hatcher jp. Curr Pharm Biotechnol. 2011 Oct;12(10):1660-70. doi: 10.2174/138920111798357384. Curr Pharm Biotechnol. 2011. PMID: 21466448 Review.
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.
Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP, Chong E, Mander PK, Green PJ, Billinton A, Fulleylove M, Lancaster HC, Smith JC, Bailey LT, Wise A, Brown AJ, Richardson JC, Chessell IP. Staton PC, et al. Among authors: hatcher jp. Pain. 2008 Sep 30;139(1):225-236. doi: 10.1016/j.pain.2008.04.006. Epub 2008 May 27. Pain. 2008. PMID: 18502582
Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.
Thornton P, Hatcher JP, Robinson I, Sargent B, Franzén B, Martino G, Kitching L, Glover CP, Anderson D, Forsmo-Bruce H, Low CP, Cusdin F, Dosanjh B, Williams W, Steffen AC, Thompson S, Eklund M, Lloyd C, Chessell I, Hughes J. Thornton P, et al. Among authors: hatcher jp. Neurosci Lett. 2013 Jun 17;545:23-8. doi: 10.1016/j.neulet.2013.04.007. Epub 2013 Apr 19. Neurosci Lett. 2013. PMID: 23603259
40 results