Wong H - Search Results

1

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, Piechocka-Trocha A, Wong H, Jeng E, Nixon DF, Ho YC, Siliciano RF, Walker BD, Jones RB. Huang SH, et al. Among authors: wong h. J Clin Invest. 2018 Feb 1;128(2):876-889. doi: 10.1172/JCI97555. Epub 2018 Jan 22. J Clin Invest. 2018. PMID: 29355843 Free PMC article.

2

IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization.

Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA, Rhode PR, Wong HC. Han KP, et al. Cytokine. 2011 Dec;56(3):804-10. doi: 10.1016/j.cyto.2011.09.028. Epub 2011 Oct 22. Cytokine. 2011. PMID: 22019703 Free PMC article.

3

Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma.

Xu W, Jones M, Liu B, Zhu X, Johnson CB, Edwards AC, Kong L, Jeng EK, Han K, Marcus WD, Rubinstein MP, Rhode PR, Wong HC. Xu W, et al. Cancer Res. 2013 May 15;73(10):3075-86. doi: 10.1158/0008-5472.CAN-12-2357. Epub 2013 May 3. Cancer Res. 2013. PMID: 23644531 Free PMC article.

4

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8⁺ T cells into innate-like effector cells with antitumor activity.

Wong HC, Jeng EK, Rhode PR. Wong HC, et al. Oncoimmunology. 2013 Nov 1;2(11):e26442. doi: 10.4161/onci.26442. Epub 2013 Oct 9. Oncoimmunology. 2013. PMID: 24404427 Free PMC article.

5

In Vivo Activation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice.

Seay K, Church C, Zheng JH, Deneroff K, Ochsenbauer C, Kappes JC, Liu B, Jeng EK, Wong HC, Goldstein H. Seay K, et al. Among authors: wong hc. J Virol. 2015 Jun;89(12):6264-74. doi: 10.1128/JVI.00563-15. Epub 2015 Apr 1. J Virol. 2015. PMID: 25833053 Free PMC article.

6

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model.

Mathios D, Park CK, Marcus WD, Alter S, Rhode PR, Jeng EK, Wong HC, Pardoll DM, Lim M. Mathios D, et al. Int J Cancer. 2016 Jan 1;138(1):187-94. doi: 10.1002/ijc.29686. Epub 2015 Jul 28. Int J Cancer. 2016. PMID: 26174883 Free PMC article.

7

The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas.

Rosario M, Liu B, Kong L, Collins LI, Schneider SE, Chen X, Han K, Jeng EK, Rhode PR, Leong JW, Schappe T, Jewell BA, Keppel CR, Shah K, Hess B, Romee R, Piwnica-Worms DR, Cashen AF, Bartlett NL, Wong HC, Fehniger TA. Rosario M, et al. Clin Cancer Res. 2016 Feb 1;22(3):596-608. doi: 10.1158/1078-0432.CCR-15-1419. Epub 2015 Sep 30. Clin Cancer Res. 2016. PMID: 26423796 Free PMC article.

8

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models.

Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L, Kong L, Edwards AC, Han K, Shi S, Alter S, Sacha JB, Jeng EK, Cai W, Wong HC. Rhode PR, et al. Among authors: wong hc. Cancer Immunol Res. 2016 Jan;4(1):49-60. doi: 10.1158/2326-6066.CIR-15-0093-T. Epub 2015 Oct 28. Cancer Immunol Res. 2016. PMID: 26511282 Free PMC article.

9

Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC.

Basher F, Jeng EK, Wong H, Wu J. Basher F, et al. Among authors: wong h. Oncotarget. 2016 Jan 5;7(1):814-30. doi: 10.18632/oncotarget.6416. Oncotarget. 2016. PMID: 26625316 Free PMC article.

10

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.

Kim PS, Kwilas AR, Xu W, Alter S, Jeng EK, Wong HC, Schlom J, Hodge JW. Kim PS, et al. Oncotarget. 2016 Mar 29;7(13):16130-45. doi: 10.18632/oncotarget.7470. Oncotarget. 2016. PMID: 26910920 Free PMC article.

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