Metcalf CS - Search Results

1

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.

Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Metcalf CS, et al. Epilepsia. 2018 Mar;59(3):724-735. doi: 10.1111/epi.14005. Epub 2018 Jan 23. Epilepsia. 2018. PMID: 29360159

2

Status epilepticus produces chronic alterations in cardiac sympathovagal balance.

Metcalf CS, Radwanski PB, Bealer SL. Metcalf CS, et al. Epilepsia. 2009 Apr;50(4):747-54. doi: 10.1111/j.1528-1167.2008.01764.x. Epilepsia. 2009. PMID: 18727681 Free article.

3

Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.

Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Zhang L, et al. Among authors: metcalf cs. Mol Pharm. 2013 Feb 4;10(2):574-85. doi: 10.1021/mp300236v. Epub 2013 Jan 15. Mol Pharm. 2013. PMID: 23259957

4

Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models.

Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Metcalf CS, et al. J Pharmacol Exp Ther. 2015 Jan;352(1):185-93. doi: 10.1124/jpet.114.219063. Epub 2014 Oct 27. J Pharmacol Exp Ther. 2015. PMID: 25347995 Free PMC article.

5

Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.

Metcalf CS, Klein BD, McDougle DR, Zhang L, Kaufmann D, Bulaj G, White HS. Metcalf CS, et al. Epilepsia. 2017 Feb;58(2):239-246. doi: 10.1111/epi.13647. Epub 2017 Jan 18. Epilepsia. 2017. PMID: 28098336 Free PMC article.

6

Efficacy of mGlu₂ -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.

Metcalf CS, Klein BD, Smith MD, Pruess T, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Metcalf CS, et al. Epilepsia. 2017 Mar;58(3):484-493. doi: 10.1111/epi.13659. Epub 2017 Feb 6. Epilepsia. 2017. PMID: 28166368

7

Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.

Metcalf CS, Smith MD, Klein BD, McDougle DR, Zhang L, Bulaj G. Metcalf CS, et al. Neurochem Res. 2017 Jul;42(7):1983-1994. doi: 10.1007/s11064-017-2229-5. Epub 2017 Apr 6. Neurochem Res. 2017. PMID: 28382595 Free PMC article.

8

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.

Metcalf CS, West PJ, Thomson KE, Edwards SF, Smith MD, White HS, Wilcox KS. Metcalf CS, et al. Epilepsia. 2017 Jun;58(6):1073-1084. doi: 10.1111/epi.13764. Epub 2017 Apr 27. Epilepsia. 2017. PMID: 28449218 Free PMC article.

9

Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH. Klein BD, et al. Among authors: metcalf cs. Neurochem Res. 2017 Jul;42(7):1939-1948. doi: 10.1007/s11064-017-2287-8. Epub 2017 May 6. Neurochem Res. 2017. PMID: 28478594

10

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.

West PJ, Saunders GW, Billingsley P, Smith MD, White HS, Metcalf CS, Wilcox KS. West PJ, et al. Among authors: metcalf cs. Epilepsia. 2018 Nov;59(11):2035-2048. doi: 10.1111/epi.14563. Epub 2018 Oct 17. Epilepsia. 2018. PMID: 30328622 Free PMC article.

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