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iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.
Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE. Qing X, et al. Among authors: mak tw. J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5. J Clin Invest. 2018. PMID: 29369823 Free PMC article.
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. Brüstle A, et al. Among authors: mak tw. J Clin Invest. 2012 Dec;122(12):4698-709. doi: 10.1172/JCI63528. Epub 2012 Nov 1. J Clin Invest. 2012. PMID: 23114599 Free PMC article.
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. Issuree PD, et al. Among authors: mak tw. J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348744 Free PMC article.
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.
Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford HC, McIlwain DR, Mak TW, Salmon JE, Blobel CP. Li X, et al. Among authors: mak tw. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918388 Free PMC article.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA. Maney SK, et al. Among authors: mak tw. Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356. Sci Signal. 2015. PMID: 26535007 Free PMC article.
1,086 results