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Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe.
Pietrobono S, Santini R, Gagliardi S, Dapporto F, Colecchia D, Chiariello M, Leone C, Valoti M, Manetti F, Petricci E, Taddei M, Stecca B. Pietrobono S, et al. Among authors: gagliardi s. Cell Death Dis. 2018 Feb 2;9(2):142. doi: 10.1038/s41419-017-0142-0. Cell Death Dis. 2018. PMID: 29396391 Free PMC article.
Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
Pietrobono S, Gaudio E, Gagliardi S, Zitani M, Carrassa L, Migliorini F, Petricci E, Manetti F, Makukhin N, Bond AG, Paradise BD, Ciulli A, Fernandez-Zapico ME, Bertoni F, Stecca B. Pietrobono S, et al. Among authors: gagliardi s. Oncogene. 2021 Jun;40(22):3799-3814. doi: 10.1038/s41388-021-01783-9. Epub 2021 May 6. Oncogene. 2021. PMID: 33958721 Free PMC article.
ERK5 is activated by oncogenic BRAF and promotes melanoma growth.
Tusa I, Gagliardi S, Tubita A, Pandolfi S, Urso C, Borgognoni L, Wang J, Deng X, Gray NS, Stecca B, Rovida E. Tusa I, et al. Among authors: gagliardi s. Oncogene. 2018 May;37(19):2601-2614. doi: 10.1038/s41388-018-0164-9. Epub 2018 Feb 27. Oncogene. 2018. PMID: 29483645 Free PMC article.
Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21.
Tubita A, Lombardi Z, Tusa I, Lazzeretti A, Sgrignani G, Papini D, Menconi A, Gagliardi S, Lulli M, Dello Sbarba P, Esparís-Ogando A, Pandiella A, Stecca B, Rovida E. Tubita A, et al. Among authors: gagliardi s. Cancer Res. 2022 Feb 1;82(3):447-457. doi: 10.1158/0008-5472.CAN-21-0993. Epub 2021 Nov 19. Cancer Res. 2022. PMID: 34799355 Free PMC article.
Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer's disease.
Morasso C, Truffi M, Tinelli V, Stivaktakis P, Di Gerlando R, Francesca D, Perini G, Faisal M, Aid J, Noridov B, Lee B, Barbieri L, Negri S, Nikitovic D, Thrapsanioti LN, Tsatsakis A, Cereda C, Bonizzi A, Mazzucchelli S, Prosperi D, Hickey MA, Corsi F, Gagliardi S. Morasso C, et al. Among authors: gagliardi s. J Nanobiotechnology. 2024 Nov 17;22(1):718. doi: 10.1186/s12951-024-02897-4. J Nanobiotechnology. 2024. PMID: 39551771 Free PMC article.
A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer's Disease.
Ferrari RR, Fantini V, Garofalo M, Di Gerlando R, Dragoni F, Rizzo B, Spina E, Rossi M, Calatozzolo C, Profka X, Ceroni M, Guaita A, Davin A, Gagliardi S, Poloni TE. Ferrari RR, et al. Among authors: gagliardi s. Int J Mol Sci. 2024 Oct 16;25(20):11117. doi: 10.3390/ijms252011117. Int J Mol Sci. 2024. PMID: 39456899 Free PMC article.
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.
Saez-Atienzar S, Souza CDS, Chia R, Beal SN, Lorenzini I, Huang R, Levy J, Burciu C, Ding J, Gibbs JR, Jones A, Dewan R, Pensato V, Peverelli S, Corrado L, van Vugt JJFA, van Rheenen W, Tunca C, Bayraktar E, Xia M; International ALS Genomics Consortium; ITALSGEN Consortium; SLAGEN Consortium; Project MinE ALS Sequencing Consortium; Iacoangeli A, Shatunov A, Tiloca C, Ticozzi N, Verde F, Mazzini L, Kenna K, Al Khleifat A, Opie-Martin S, Raggi F, Filosto M, Piccinelli SC, Padovani A, Gagliardi S, Inghilleri M, Ferlini A, Vasta R, Calvo A, Moglia C, Canosa A, Manera U, Grassano M, Mandrioli J, Mora G, Lunetta C, Tanel R, Trojsi F, Cardinali P, Gallone S, Brunetti M, Galimberti D, Serpente M, Fenoglio C, Scarpini E, Comi GP, Corti S, Del Bo R, Ceroni M, Pinter GL, Taroni F, Bella ED, Bersano E, Curtis CJ, Lee SH, Chung R, Patel H, Morrison KE, Cooper-Knock J, Shaw PJ, Breen G, Dobson RJB, Dalgard CL; American Genome Center; Scholz SW, Al-Chalabi A, van den Berg LH, McLaughlin R, Hardiman O, Cereda C, Sorarù G, D'Alfonso S, Chandran S, Pal S, Ratti A, Gellera C, Johnson K, Doucet-O'Hare T, Pasternack N, Wang T, Nath A, Siciliano G, Silani V, Başak AN, Veldink JH, Camu W, Glass J… See abstract for full author list ➔ Saez-Atienzar S, et al. Among authors: gagliardi s. Cell Genom. 2024 Nov 13;4(11):100679. doi: 10.1016/j.xgen.2024.100679. Epub 2024 Oct 21. Cell Genom. 2024. PMID: 39437787 Free PMC article.
242 results