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Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Nikonova AS, Deneka AY, Kiseleva AA, Korobeynikov V, Gaponova A, Serebriiskii IG, Kopp MC, Hensley HH, Seeger-Nukpezah TN, Somlo S, Proia DA, Golemis EA. Nikonova AS, et al. Among authors: somlo s. FASEB J. 2018 May;32(5):2735-2746. doi: 10.1096/fj.201700909R. Epub 2018 Jan 10. FASEB J. 2018. PMID: 29401581 Free PMC article.
These studies identify a new biologic activity for HSP90 and support a cilia-based mechanism for cyst repression.-Nikonova, A. S., Deneka, A. Y., Kiseleva, A. A., Korobeynikov, V., Gaponova, A., Serebriiskii, I. ...C., Hensley, H. H., Seeger-Nukpezah, T. N., Somlo, …
These studies identify a new biologic activity for HSP90 and support a cilia-based mechanism for cyst repression.-Nikonova, A. S., De …
Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S. Davila S, et al. Among authors: somlo s. Nat Genet. 2004 Jun;36(6):575-7. doi: 10.1038/ng1357. Epub 2004 May 9. Nat Genet. 2004. PMID: 15133510
Triptolide reduces cystogenesis in a model of ADPKD.
Leuenroth SJ, Bencivenga N, Igarashi P, Somlo S, Crews CM. Leuenroth SJ, et al. Among authors: somlo s. J Am Soc Nephrol. 2008 Sep;19(9):1659-62. doi: 10.1681/ASN.2008030259. Epub 2008 Jul 23. J Am Soc Nephrol. 2008. PMID: 18650476 Free PMC article.
185 results